Khindivi Dosage
Generic name: Hydrocortisone 1mg in 1mL
Dosage form: oral solution
Drug class: Glucocorticoids
Medically reviewed by Drugs.com. Last updated on May 29, 2025.
Important Considerations for Dosing
- Individualize the dose for each patient, using the lowest possible dosage.
- Monitor patients for symptoms of under and/or overtreatment including signs and symptoms of adrenocortical insufficiency, linear growth, and weight gain. Adjust doses accordingly.
- When stress dosing is needed (during episodes of acute febrile illness, gastroenteritis, surgery or major trauma) use a different hydrocortisone-containing drug product..
Recommended Dosage and Administration
- The recommended starting replacement dosage of KHINDIVI is 8 to 10 mg/m2 daily administered orally with or without food. Higher doses may be needed based on the patient's age and symptoms of the disease. Use of lower starting dose may be sufficient in patients with residual but decreased endogenous cortisol production.
- Round the dose to the nearest 0.5 mg or 1 mg.
- Divide the total daily dose into 3 doses and administer 3 times daily. Older pediatric patients may have their daily dose divided by 2 and administered twice daily.
- Administer KHINDIVI using the oral syringe provided by the pharmacy.
- KHINDIVI may be administered through a gastric tube. Flush gastric tube with 20 mL of water to ensure the entire dose is delivered.
Discontinue KHINDIVI Due to Adverse Reactions Associated with Inactive Ingredients
- KHINDIVI contains the inactive ingredients polyethylene glycol 400, propylene glycol, and glycerin, which have been associated with hyperosmolarity, metabolic acidosis, hypoglycemia, hepato-renal injury, central nervous system toxicity, and gastrointestinal adverse reactions. If patient presents with adverse reactions that could be related to these conditions, monitor the patient, and consider discontinuation of KHINDIVI and switching to another hydrocortisone product.
Switching to KHINDIVI from Other Oral Hydrocortisone Formulations
- When switching patients to KHINDIVI from other oral hydrocortisone formulations to KHINDIVI use the same total daily hydrocortisone dosage. After switching to KHINDIVI, monitor patients for symptoms of adrenocortical insufficiency. If symptoms of adrenal insufficiency occur after switching, increase the total daily dosage of KHINDIVI.
Frequently asked questions
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- Can you use hydrocortisone cream on babies?
- Does hydrocortisone cream stop itching?
More about Khindivi (hydrocortisone)
- Check interactions
- Compare alternatives
- Drug images
- Side effects
- During pregnancy
- FDA approval history
- Drug class: glucocorticoids
- Breastfeeding
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Further information
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