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Kazano Dosage

Generic name: ALOGLIPTIN BENZOATE 12.5mg, Metformin hydrochloride 500mg
Dosage form: tablet, film coated
Drug class: Antidiabetic combinations

Medically reviewed by Last updated on Aug 7, 2023.

Recommended Dosage

  • Individualize the starting dosage of KAZANO based on the patient's current regimen.
  • KAZANO should be taken orally twice daily with food with gradual dose escalation to reduce the gastrointestinal (GI) side effects due to metformin. Do not split tablets.
  • Adjust the dosage based on effectiveness and tolerability while not exceeding the maximum recommended daily dose of 25 mg alogliptin and 2000 mg metformin hydrochloride (HCl).

Recommendations for Use in Renal Impairment

Assess renal function prior to initiation of KAZANO and periodically thereafter.

KAZANO is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below 30 mL/min/1.73 m2 [see Contraindications (4), Warnings and Precautions (5.1)].

KAZANO is not recommended in patients with an eGFR between 30 and 59 mL/min/1.73 m2 because these patients require a lower daily dosage of alogliptin than what is available in the fixed combination KAZANO product.

Kazano requires no dose adjustment in patients with an eGFR of 60 mL/min/1.73 m2 or greater.

Discontinuation for Iodinated Contrast Imaging Procedures

Discontinue KAZANO at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR between 30 and 60 mL/min/1.73 m2; in patients with a history of liver disease, alcoholism or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure; restart KAZANO if renal function is stable [see Warnings and Precautions (5.1)].

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.