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Isovue 300 Dosage

Medically reviewed by Last updated on Nov 7, 2020.

Generic name: IOPAMIDOL 612mg in 1mL
Dosage form: injection, solution


Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Iopamidol solutions should be used only if clear and within the normal colorless to pale yellow range. Discard any product which shows signs of crystallization or damage to the container-closure system, which includes the glass container, stopper and/or crimp.

It is desirable that solutions of radiopaque diagnostic agents for intravascular use be at body temperature when injected. Sterile techniques must be used with any intravascular injection.
The transferring of ISOVUE from the ISOVUE Imaging Bulk Package container should be performed utilizing aseptic technique. The Imaging Bulk Package closure may be penetrated only one time, with a suitable sterile component of the automated contrast injection system, contrast management system, or contrast media transfer set approved or cleared for use with this Imaging Bulk Package.
Patients should be well hydrated prior to and following ISOVUE (Iopamidol Injection) administration.
As with all radiopaque contrast agents, only the lowest dose of ISOVUE necessary to obtain adequate visualization should be used. A lower dose reduces the possibility of an adverse reaction. Most procedures do not require use of either a maximum dose or the highest available concentration of ISOVUE; the combination of dose and ISOVUE concentration to be used should be carefully individualized, and factors such as age, body size, size of the vessel and its blood flow rate, anticipated pathology and degree and extent of opacification required, structure(s) or area to be examined, disease processes affecting the patient, and equipment and technique to be employed should be considered.

Cerebral Arteriography

ISOVUE-300 (Iopamidol Injection, 300 mg iodine/mL) should be used. The usual individual injection by carotid puncture or transfemoral catheterization is 8 to 12 mL, with total multiple doses up to 90 mL.

Peripheral Arteriography

ISOVUE-300 usually provides adequate visualization. For injection into the femoral artery or subclavian artery, 5 to 40 mL may be used; for injection into the aorta for a distal runoff, 25 to 50 mL may be used. Doses up to a total of 250 mL of ISOVUE-300 have been administered during peripheral arteriography.

Peripheral Venography (Phlebography)

ISOVUE-300 should be used. The usual dose is 15 mL to 100 mL per lower extremity. The combined total dose for multiple injections should not exceed 230 mL.

Selective Visceral Arteriography and Aortography

ISOVUE-370 (Iopamidol Injection, 370 mg iodine/mL) should be used. Doses up to 50 mL may be required for injection into the larger vessels such as the aorta or celiac artery; doses up to 10 mL may be required for injection into the renal arteries. Often lower doses will be sufficient. The combined total dose for multiple injections has not exceeded 225 mL.

Pediatric Angiocardiography

ISOVUE-370 should be used. Pediatric angiocardiography may be performed by injection into a large peripheral vein or be direct characterization of the heart. The usual dose range for single injections is provided in the following table:

Single Injection
Usual Dose Range
Age mL
<2 years 10–15
2–9 years 15–30
10–18 years 20–50

The usual recommended dose for cumulative injections is provided in the following table.

Cumulative Injection
Usual Recommended Dose
Age mL
<2 years 40
2–4 years 50
5–9 years 100
10–18 years 125

Coronary Arteriography and Ventriculography

ISOVUE-370 should be used. The usual dose for selective coronary artery injections is 2 to 10 mL. The usual dose for ventriculography, or for nonselective opacification of multiple coronary arteries following injection at the aortic root is 25 to 50 mL. The total dose for combined procedures has not exceeded 200 mL. EKG monitoring is essential.

Computed Tomography

CT OF THE HEAD: The suggested dose for ISOVUE-300 is 100 to 200 mL by intravenous administration. Imaging may be performed immediately after completion of administration.
CT OF THE BODY: The usual adult dose range for ISOVUE-300 is 100-to 200 mL administered by rapid intravenous infusion or bolus injection.
Equivalent doses of ISOVUE-370 based on organically bound iodine content may also be used.
The total dose for either CT procedure should not exceed 60 grams of iodine.

Pediatric Computed Tomography

The dosage recommended for use in children for contrast enhanced computed tomography is 1.0 mL/kg to 3.0 mL/kg for ISOVUE-300. It should not be necessary to exceed a total dose of 30 grams of iodine.

Drug Incompatibilities

Many radiopaque contrast agents are incompatible in vitro with some antihistamines and many other drugs; therefore, no other pharmaceuticals should be admixed with contrast agents.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.