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Insulin Inhalation, Rapid Acting Dosage

Medically reviewed by Drugs.com. Last updated on Mar 21, 2024.

Applies to the following strengths: 4 units; 4 units- 8 units; 8 units-12 units; 1 mg and 3 mg; 1 mg; 3 mg; 8 units; 12 units; 4 units-8 units-12 units

Usual Adult Dose for Diabetes Type 2

Insulin-naive:
Initial dose: 4 units via oral inhalation at the beginning of each meal
Maintenance dose: Adjust dose based on individual's metabolic needs, glucose monitoring results, and glycemic goals

Switching from Subcutaneous Mealtime Insulin:
Dose conversion as follows:
4 units inhaled insulin replaces up to 4 units of subcutaneous mealtime insulin
8 units inhaled insulin replaces 5 to 8 units of subcutaneous mealtime insulin
12 units inhaled insulin replaces 9 to 12 units of subcutaneous mealtime insulin
16 units inhaled insulin replaces 13 to 16 units of subcutaneous mealtime insulin
20 units inhaled insulin replaces 17 to 20 units of subcutaneous mealtime insulin
24 units inhaled insulin replaces 21 to 24 units of subcutaneous mealtime insulin

Switching from Subcutaneous Pre-mixed insulin:


Comments:

Use: Inhaled insulin is a rapid acting insulin for use in adult patients with diabetes mellitus to improve glycemic control.

Usual Adult Dose for Diabetes Type 1

Insulin-naive:
Initial dose: 4 units via oral inhalation at the beginning of each meal
Maintenance dose: Adjust dose based on individual's metabolic needs, glucose monitoring results, and glycemic goals

Switching from Subcutaneous Mealtime Insulin:
Dose conversion as follows:
4 units inhaled insulin replaces up to 4 units of subcutaneous mealtime insulin
8 units inhaled insulin replaces 5 to 8 units of subcutaneous mealtime insulin
12 units inhaled insulin replaces 9 to 12 units of subcutaneous mealtime insulin
16 units inhaled insulin replaces 13 to 16 units of subcutaneous mealtime insulin
20 units inhaled insulin replaces 17 to 20 units of subcutaneous mealtime insulin
24 units inhaled insulin replaces 21 to 24 units of subcutaneous mealtime insulin

Switching from Subcutaneous Pre-mixed insulin:


Comments:

Use: Inhaled insulin is a rapid acting insulin for use in adult patients with diabetes mellitus to improve glycemic control.

Renal Dose Adjustments

Use with caution. Frequent glucose monitoring and dose adjustment may be necessary.

Liver Dose Adjustments

Use with caution. Frequent glucose monitoring and dose adjustment may be necessary.

Precautions

US REMS: The US FDA requires a Risk Evaluation and Mitigation Strategy (REMS) for Afrezza. It includes a communication plan. For additional information: www.fda.gov/REMS

US BOXED WARNINGS:


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration Advice:


Storage requirements:

General:

Monitoring:

Patient Advice:

More about insulin inhalation, rapid acting

Patient resources

Other brands

Afrezza, Exubera

Professional resources

Other brands

Afrezza

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.