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Icosapent Dosage

Medically reviewed by Drugs.com. Last updated on Feb 13, 2020.

Applies to the following strengths: 1 g; 0.5 g

Usual Adult Dose for Hypertriglyceridemia

2 g orally twice a day with food

Comments:
-Patients should be placed on an appropriate lipid-lowering diet and exercise regimen before initiating therapy and should continue this diet and exercise regimen during therapy.

Uses:
-As an adjunct to diet to reduce triglyceride (TG) levels in patients with severe (500 mg/dL or greater) hypertriglyceridemia.
-As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adult patients with triglyceride levels of 150 mg/dL or higher and established cardiovascular disease or diabetes mellitus and 2 or more additional risk factors for cardiovascular disease.

Usual Adult Dose for Cardiovascular Risk Reduction

2 g orally twice a day with food

Comments:
-Patients should be placed on an appropriate lipid-lowering diet and exercise regimen before initiating therapy and should continue this diet and exercise regimen during therapy.

Uses:
-As an adjunct to diet to reduce triglyceride (TG) levels in patients with severe (500 mg/dL or greater) hypertriglyceridemia.
-As an adjunct to maximally tolerated statin therapy to reduce the risk of myocardial infarction, stroke, coronary revascularization, and unstable angina requiring hospitalization in adult patients with triglyceride levels of 150 mg/dL or higher and established cardiovascular disease or diabetes mellitus and 2 or more additional risk factors for cardiovascular disease.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

CONTRAINDICATIONS:
-Known hypersensitivity to active substance or any of its components

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Take orally with food
-Swallow capsules whole; do not break open, crush, dissolve, or chew

Missed dose: If a dose is missed, take as soon as remembered, however, if it is close to the next dose do not double the dose

General:
-The effect of this drug on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.
-Prior to initiating therapy, medical problems known to affect hypertriglyceridemia such as diabetes mellitus, hypothyroidism, and alcohol intake should be managed, and medications known to exacerbate hypertriglyceridemia (such as beta blockers, thiazides, estrogens) should be discontinued or changed, if possible.
-Patients should be placed on a lipid lowering diet and exercise regimen prior to initiating therapy and this should continue during treatment.

Monitoring:
-Assess lipid levels prior to initiating therapy
-Monitor ALT and AST periodically during therapy in patients with hepatic impairment
-Monitor bleeding time in patients on concomitant agents affecting coagulation

Patient advice:
-Patients should be instructed to read the US FDA-approved patient labeling (Patient Information).
-Patients should be instructed to follow the diet and exercise regimen they have been prescribed.
-Patients should be advised to discontinue therapy and seek medical attention as appropriate if allergic reactions develop.
-Patients should understand that this drug may increase their risk of bleeding and should notify their healthcare provider promptly if they experience increased bleeding.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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