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Hydrocortisone / Neomycin / Polymyxin B Ophthalmic Dosage

Medically reviewed on December 15, 2017.

Applies to the following strengths: 1%-0.35%-10000 units/mL

Usual Adult Dose for Uveitis

Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on severity of condition; may be used more frequently if needed

Comments:
-If signs/symptoms fail to improve after 2 days of treatment, the patient should be re-evaluated.

Uses:
-For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists
-Ocular corticosteroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of corticosteroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation; also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns; or penetration of foreign bodies.
-The anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa; this drug does not provide adequate coverage against Serratia marcescens and Streptococci including S pneumoniae

Usual Adult Dose for Ocular Infection

Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on severity of condition; may be used more frequently if needed

Comments:
-If signs/symptoms fail to improve after 2 days of treatment, the patient should be re-evaluated.

Uses:
-For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists
-Ocular corticosteroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of corticosteroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation; also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns; or penetration of foreign bodies.
-The anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa; this drug does not provide adequate coverage against Serratia marcescens and Streptococci including S pneumoniae

Usual Adult Dose for Bacterial Conjunctivitis

Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on severity of condition; may be used more frequently if needed

Comments:
-If signs/symptoms fail to improve after 2 days of treatment, the patient should be re-evaluated.

Uses:
-For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists
-Ocular corticosteroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of corticosteroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation; also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns; or penetration of foreign bodies.
-The anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa; this drug does not provide adequate coverage against Serratia marcescens and Streptococci including S pneumoniae

Usual Adult Dose for Keratitis

Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on severity of condition; may be used more frequently if needed

Comments:
-If signs/symptoms fail to improve after 2 days of treatment, the patient should be re-evaluated.

Uses:
-For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists
-Ocular corticosteroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of corticosteroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation; also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns; or penetration of foreign bodies.
-The anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa; this drug does not provide adequate coverage against Serratia marcescens and Streptococci including S pneumoniae

Usual Adult Dose for Keratoconjunctivitis

Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on severity of condition; may be used more frequently if needed

Comments:
-If signs/symptoms fail to improve after 2 days of treatment, the patient should be re-evaluated.

Uses:
-For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists
-Ocular corticosteroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of corticosteroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation; also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns; or penetration of foreign bodies.
-The anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa; this drug does not provide adequate coverage against Serratia marcescens and Streptococci including S pneumoniae

Usual Adult Dose for Blepharitis

Instill 1 to 2 drops in the affected eye(s) every 3 to 4 hours, depending on severity of condition; may be used more frequently if needed

Comments:
-If signs/symptoms fail to improve after 2 days of treatment, the patient should be re-evaluated.

Uses:
-For the treatment of steroid-responsive inflammatory ocular conditions for which a corticosteroid is indicated and where bacterial infection or a risk of bacterial infection exists
-Ocular corticosteroids are indicated in inflammatory conditions of the palpebral and bulbar conjunctiva, cornea, and anterior segment of the globe where the inherent risk of corticosteroid use in certain infective conjunctivitides is accepted to obtain a diminution in edema and inflammation; also indicated in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns; or penetration of foreign bodies.
-The anti-infective component of this drug is active against the following common bacterial eye pathogens: Staphylococcus aureus, Escherichia coli, Haemophilus influenzae, Klebsiella/Enterobacter species, Neisseria species, and Pseudomonas aeruginosa; this drug does not provide adequate coverage against Serratia marcescens and Streptococci including S pneumoniae

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Shake well before use.
-A maximum of 20 mL should be prescribed initially and should not be refilled without further evaluation of the patient's condition.

Storage requirements:
-Keep container tightly closed.

Monitoring:
-Ocular: Monitor intraocular pressure frequently or routinely, especially if used for longer than 10 days.

Patient advice:
-Care should be taken to avoid touching the tip of the bottle to the eye, eyelids, fingers, or to any other surface.
-Use of the bottle by more than 1 person may spread infection and should be avoided.
-Serious damage to the eye and subsequent loss of vision may result from using contaminated products.
-If the condition persists or gets worse, or if a rash or allergic reaction develops, stop use immediately and consult a physician; do not use this product If you have an allergy to any of the ingredients.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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