Hydrocortisone / neomycin / polymyxin b ophthalmic Pregnancy and Breastfeeding Warnings

Brand names: Cortisporin Ophthalmic Suspension, Cortomycin Suspension, Neo/PolyB/HC

Medically reviewed by Drugs.com. Last updated on Nov 20, 2023.

Hydrocortisone / neomycin / polymyxin b ophthalmic Pregnancy Warnings

This drug should be used during pregnancy only if the potential benefit outweighs the potential risk to the fetus.

US FDA pregnancy category: C

Animal studies have not been reported. Corticosteroids have been found to be teratogenic in rabbits when applied topically at concentrations of 0.5% and 15%. There are no controlled data in human pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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Hydrocortisone / neomycin / polymyxin b ophthalmic Breastfeeding Warnings

A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Unknown
Excreted into animal milk: Data not available

Comments: The effects in the nursing infant are unknown.

It is unknown whether topically administered corticosteroids could result in sufficient systemic absorption to produce detectable levels in breast milk; however, systemically administered corticosteroids may appear in breast milk and could suppress growth, interfere with endogenous corticosteroid production, or cause untoward effects.

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Further information

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