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Gralise Dosage

Generic name: GABAPENTIN 300mg
Dosage form: tablet, film coated
Drug class: Gamma-aminobutyric acid analogs

Medically reviewed by Last updated on Mar 1, 2023.

Postherpetic Neuralgia

Do not use GRALISE interchangeably with other gabapentin products.

Titrate GRALISE to an 1,800 mg dose taken orally once daily with the evening meal. GRALISE tablets should be swallowed whole. Do not split, crush, or chew the tablets.

If GRALISE dosing is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum of one week or longer (at the discretion of the prescriber).

In adults with postherpetic neuralgia, GRALISE therapy should be initiated and titrated as follows:

Table 1: GRALISE Recommended Titration Schedule
Day 1 Day 2 Days 3-6 Days 7-10 Days 11-14 Day 15
Daily Dose 300 mg 600 mg 900 mg 1,200 mg 1,500 mg 1,800 mg

Patients with Renal Impairment

In patients with stable renal function, creatinine clearance (CCr) can be reasonably well estimated using the equation of Cockcroft and Gault:
For females CCr=(0.85)(140-age)(weight)/[(72)(SCr)]
For males CCr=(140-age)(weight)/[(72)(SCr)]
where age is in years, weight is in kilograms and SCr is serum creatinine in mg/dL.

The dose of GRALISE should be adjusted in patients with reduced renal function, according to Table 2. Patients with reduced renal function must initiate GRALISE at a daily dose of 300 mg. GRALISE should be titrated following the schedule outlined in Table 1. Daily dosing in patients with reduced renal function must be individualized based on tolerability and desired clinical benefit.

Table 2: GRALISE Dosage Based on Renal Function
Once-daily dosing
Creatinine Clearance (mL/min) GRALISE Dose (once daily with evening meal)
≥ 60 1,800 mg
30 - 60 600 mg to 1,800 mg
< 30 GRALISE should not be administered
patients receiving hemodialysis GRALISE should not be administered

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.