Medically reviewed by Drugs.com. Last updated on Feb 17, 2021.
Generic name: GABAPENTIN 300mg
Dosage form: tablet, film coated
Do not use GRALISE interchangeably with other gabapentin products.
Titrate GRALISE to an 1800 mg dose taken orally once daily with the evening meal. GRALISE tablets should be swallowed whole. Do not split, crush, or chew the tablets.
If GRALISE dose is reduced, discontinued, or substituted with an alternative medication, this should be done gradually over a minimum of one week or longer (at the discretion of the prescriber).
In adults with postherpetic neuralgia, GRALISE therapy should be initiated and titrated as follows:
|Day 1||Day 2||Days 3-6||Days 7-10||Days 11-14||Day 15|
|Daily Dose||300 mg||600 mg||900 mg||1200 mg||1500 mg||1800 mg|
Patients with Renal Impairment
In patients with stable renal function, creatinine clearance (CCr) can be reasonably well estimated using the equation of Cockcroft and Gault:
For females CCr=(0.85)(140-age)(weight)/[(72)(SCr)]
For males CCr=(140-age)(weight)/[(72)(SCr)]
where age is in years, weight is in kilograms and SCr is serum creatinine in mg/dL.
The dose of GRALISE should be adjusted in patients with reduced renal function, according to Table 2. Patients with reduced renal function must initiate GRALISE at a daily dose of 300 mg. GRALISE should be titrated following the schedule outlined in Table 1. Daily dosing in patients with reduced renal function must be individualized based on tolerability and desired clinical benefit.
|Creatinine Clearance (mL/min)||GRALISE Dose (once daily with evening meal)|
|≥ 60||1800 mg|
|30 - 60||600 mg to 1800 mg|
|< 30||GRALISE should not be administered|
|patients receiving hemodialysis||GRALISE should not be administered|
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