Ganirelix Dosage

Medically reviewed by Drugs.com. Last updated on May 30, 2024.

Applies to the following strengths: 250 mcg/0.5 mL

Usual Adult Dose for Gonadotropin Inhibition

During the mid to late portion of the follicular phase:

Administer 250 mcg subcutaneously once a day until the day of human chorionic gonadotropin (hCG) administration

Comments:

Follicle stimulating hormone (FSH) therapy should be initiated on day 2 or 3 of the cycle.
With the assist of ultrasound, hCG should be administered when a sufficient number of follicles of adequate size are present; final maturation of follicles is induced by administering hCG.

Use: For the inhibition of premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation.

Data not available

Data not available

CONTRAINDICATIONS:

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Data not available

Administration advice:

For subcutaneous administration only
Patient should receive instructions for subcutaneous administration; convenient administration sites include abdomen around the navel or upper thigh
Rotate injection sites

Storage requirements:

Preparation techniques:

Available as single-use prefilled syringes
The prefilled syringe is affixed with a needle, the needle shield contains natural rubber latex

General:

During clinical trials, the average duration of GnRH days was 5.4 days (range: 2 to 14 days).
The administration of hCG should be withheld in cases where the ovaries are abnormally enlarged on the last day of FSH therapy to reduce the chance of developing OHSS (Ovarian Hyperstimulation Syndrome).

Monitoring:

Patient advice:

Patients should be instructed to read the US FDA-approved patient labeling.
Patients should be informed of the duration of treatment and monitoring procedures that will be required.
Patients should understand that hypersensitivity reactions have been reported and should understand what action to take if they were to experience a hypersensitivity reaction.