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Fenofibrate Dosage

Medically reviewed by Drugs.com. Last updated on Mar 8, 2021.

Applies to the following strengths: 48 mg; 145 mg; 54 mg; 160 mg; 67 mg; micronized 200 mg; 134 mg; 40 mg; 120 mg; 43 mg; 130 mg; 30 mg; 90 mg; 50 mg; 150 mg

Usual Adult Dose for Hyperlipidemia

Multiple products available:

1 capsule or tablet orally once a day (range: 90 to 200 mg per dose unit)
-Maximum dose: 1 tablet or capsule orally once a day

Some examples of branded tablets and capsules; multiple generics available:
-Antara (micronized capsules): 90 and 130 mg
-Lipofen (capsules): 150 mg
-Fenoglide (tablet): 120 mg
-Tricor (tablet): 145 mg
-Triglide (tablet): 160 mg
-Fenofibrate (micronized) capsules: 200 mg

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment.
-This drug is intended to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia.

Uses: As an adjunct therapy to diet for the treatment of primary hypercholesterolemia and mixed dyslipidemia.

Usual Adult Dose for Hyperlipoproteinemia Type IIa (Elevated LDL)

Multiple products available:

1 capsule or tablet orally once a day (range: 90 to 200 mg per dose unit)
-Maximum dose: 1 tablet or capsule orally once a day

Some examples of branded tablets and capsules; multiple generics available:
-Antara (micronized capsules): 90 and 130 mg
-Lipofen (capsules): 150 mg
-Fenoglide (tablet): 120 mg
-Tricor (tablet): 145 mg
-Triglide (tablet): 160 mg
-Fenofibrate (micronized) capsules: 200 mg

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment.
-This drug is intended to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia.

Uses: As an adjunct therapy to diet for the treatment of primary hypercholesterolemia and mixed dyslipidemia.

Usual Adult Dose for Hyperlipoproteinemia Type IIb (Elevated LDL + VLDL)

Multiple products available:

1 capsule or tablet orally once a day (range: 90 to 200 mg per dose unit)
-Maximum dose: 1 tablet or capsule orally once a day

Some examples of branded tablets and capsules; multiple generics available:
-Antara (micronized capsules): 90 and 130 mg
-Lipofen (capsules): 150 mg
-Fenoglide (tablet): 120 mg
-Tricor (tablet): 145 mg
-Triglide (tablet): 160 mg
-Fenofibrate (micronized) capsules: 200 mg

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment.
-This drug is intended to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia.

Uses: As an adjunct therapy to diet for the treatment of primary hypercholesterolemia and mixed dyslipidemia.

Usual Adult Dose for Dyslipidemia

Multiple products available:

1 capsule or tablet orally once a day (range: 90 to 200 mg per dose unit)
-Maximum dose: 1 tablet or capsule orally once a day

Some examples of branded tablets and capsules; multiple generics available:
-Antara (micronized capsules): 90 and 130 mg
-Lipofen (capsules): 150 mg
-Fenoglide (tablet): 120 mg
-Tricor (tablet): 145 mg
-Triglide (tablet): 160 mg
-Fenofibrate (micronized) capsules: 200 mg

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment.
-This drug is intended to reduce elevated low-density lipoprotein cholesterol (LDL-C), total cholesterol (Total-C), triglycerides (TG), and apolipoprotein B (Apo B), and to increase high-density lipoprotein (HDL-C) in patients with primary hypercholesterolemia or mixed dyslipidemia.

Uses: As an adjunct therapy to diet for the treatment of primary hypercholesterolemia and mixed dyslipidemia.

Usual Adult Dose for Hyperlipoproteinemia Type IV (Elevated VLDL)

Dosing is product specific; available as micronized capsules, capsules, and tablets:

MICRONIZED CAPSULES:
-Antara: Initial dose: 30 to 90 mg orally once a day; maximum dose: 90 mg/day
-Antara: Initial dose: 43 to 130 mg orally once a day; maximum dose: 130 mg/day
-Fenofibrate: Initial dose: 67 to 200 mg orally once a day; maximum dose 200 mg/day
CAPSULES:
-Lipofen: Initial dose: 50 to 150 mg orally once a day; maximum dose: 150 mg/day
TABLETS:
-Fenoglide: Initial dose: 40 to 120 mg orally once a day; maximum dose: 120 mg/day
-Tricor: Initial dose: 48 to 145 mg orally once a day: maximum dose 145 mg/day
-Fenofibrate: Initial dose: 54 to 160 mg orally once a day; maximum dose: 160 mg/day
-Triglide: 160 mg orally once a day; maximum dose: 160 mg/day

TITRATION: Individualize dose according to response and adjust as necessary following repeat lipid determinations at 4 to 8 week intervals; if lipid levels fall significantly, dose reduction should be considered.

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment with the maximum recommended dose.

Use: As an adjunct to diet for the treatment of severe hypertriglyceridemia.

Usual Adult Dose for Hyperlipoproteinemia Type V (Elevated Chylomicrons + VLDL)

Dosing is product specific; available as micronized capsules, capsules, and tablets:

MICRONIZED CAPSULES:
-Antara: Initial dose: 30 to 90 mg orally once a day; maximum dose: 90 mg/day
-Antara: Initial dose: 43 to 130 mg orally once a day; maximum dose: 130 mg/day
-Fenofibrate: Initial dose: 67 to 200 mg orally once a day; maximum dose 200 mg/day
CAPSULES:
-Lipofen: Initial dose: 50 to 150 mg orally once a day; maximum dose: 150 mg/day
TABLETS:
-Fenoglide: Initial dose: 40 to 120 mg orally once a day; maximum dose: 120 mg/day
-Tricor: Initial dose: 48 to 145 mg orally once a day: maximum dose 145 mg/day
-Fenofibrate: Initial dose: 54 to 160 mg orally once a day; maximum dose: 160 mg/day
-Triglide: 160 mg orally once a day; maximum dose: 160 mg/day

TITRATION: Individualize dose according to response and adjust as necessary following repeat lipid determinations at 4 to 8 week intervals; if lipid levels fall significantly, dose reduction should be considered.

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment with the maximum recommended dose.

Use: As an adjunct to diet for the treatment of severe hypertriglyceridemia.

Usual Adult Dose for Hypertriglyceridemia

Dosing is product specific; available as micronized capsules, capsules, and tablets:

MICRONIZED CAPSULES:
-Antara: Initial dose: 30 to 90 mg orally once a day; maximum dose: 90 mg/day
-Antara: Initial dose: 43 to 130 mg orally once a day; maximum dose: 130 mg/day
-Fenofibrate: Initial dose: 67 to 200 mg orally once a day; maximum dose 200 mg/day
CAPSULES:
-Lipofen: Initial dose: 50 to 150 mg orally once a day; maximum dose: 150 mg/day
TABLETS:
-Fenoglide: Initial dose: 40 to 120 mg orally once a day; maximum dose: 120 mg/day
-Tricor: Initial dose: 48 to 145 mg orally once a day: maximum dose 145 mg/day
-Fenofibrate: Initial dose: 54 to 160 mg orally once a day; maximum dose: 160 mg/day
-Triglide: 160 mg orally once a day; maximum dose: 160 mg/day

TITRATION: Individualize dose according to response and adjust as necessary following repeat lipid determinations at 4 to 8 week intervals; if lipid levels fall significantly, dose reduction should be considered.

Comments:
-Therapy should be withdrawn if inadequate response after 2 months of treatment with the maximum recommended dose.

Use: As an adjunct to diet for the treatment of severe hypertriglyceridemia.

Renal Dose Adjustments

Mild to moderate renal dysfunction: Initiate at lower doses and increase only after evaluating the effects of therapy on renal function and lipid levels:
-Antara (micronized capsules): Initial dose: 30 mg orally once a day; maximum dose: 90 mg orally once a day
-Antara (micronized capsules): Initial dose: 43 mg orally once a day; maximum dose: 130 mg orally once a day
-Fenofibrate (micronized capsules): Initial dose: 67 mg orally once a day; maximum dose: 200 mg orally once a day
-Fenofibrate (tablets): Initial dose: 54 mg orally once a day; maximum dose: 160 mg orally once a day
-Lipofen (capsules): Initial dose: 50 mg orally once a day; maximum dose: 150 mg orally once a day
-Fenoglide (tablets): Initial dose: 40 mg orally once a day; maximum dose: 120 mg orally once a day
-Tricor (tablets): Initial dose: 48 mg orally once a day; maximum dose: 145 mg orally once a day

Severe renal impairment: Contraindicated

Liver Dose Adjustments

Active liver disease: Contraindicated

-Monitor liver function tests, including serum ALT, AST, and total bilirubin; discontinue if signs or symptoms of liver injury develop or if elevated enzyme levels persist (ALT or AST greater than 3 times the upper limit of normal, or if accompanied by elevation of bilirubin

Dose Adjustments

Elderly: Due to the higher incidence of renal impairment in this patient population, dose selection should be based on renal function; monitor renal function during therapy

Precautions

CONTRAINDICATIONS:
-Hypersensitivity to fenofibrate, fenofibric acid, or any product excipients
-Active liver disease including primary biliary cirrhosis and unexplained persistent liver function abnormalities
-Severe renal impairment, including dialysis
-Preexisting gallbladder disease
-Lactation

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Contraindicated

Other Comments

Administration advice:
-May be taken with food to increase absorption
-Swallow capsules and tablets whole; do not break, open, crush, dissolve, or chew

Concomitant use with bile acid binding resin:
-Take at least 1 hour before or 4 to 6 hours after bile acid binding resin

Storage requirements:
-Protect from light and moisture
-Triglide(R): Dispense in original bottle

General:
-Prior to initiating therapy, diseases contributing to hyperlipidemia should be assessed and adequately treated; medications associated with elevated triglycerides should be evaluated.
-In patients with type 2 diabetes showing fasting chylomicronemia, improving glycemic control may reduce fasting triglycerides and eliminate need for drug treatment.
-Initial treatment for dyslipidemia should be dietary specific targeted at the type of lipoprotein abnormality.
-This drug has not been shown to reduce coronary heart disease morbidity and mortality in patients with type 2 diabetes mellitus.
-Markedly elevated levels of serum triglycerides (e.g. greater than 2000 mg/dL) may increase the risk of developing pancreatitis; the effect of this drug on reducing this risk has not been adequately studied.

Monitoring:
-Hematologic: Monitor RBC and WBC counts periodically during the first 12 months of therapy
-Hepatic: Measure liver function at baseline and periodically during therapy
-Metabolic: Periodically measure lipid levels and adjust dose accordingly
-Renal: Monitor renal function in patients with renal impairment or those at risk for renal insufficiency (e.g., elderly)
-More frequent PT/INR monitoring until PT/INR stabilizes

Patient advice:
-Patients should be instructed to follow a lipid-modifying diet during therapy.
-Patients should be instructed to immediately inform their physician of symptoms of liver injury (e.g., jaundice, abnormal pain, nausea, malaise, dark urine, abnormal stool, pruritus); any muscle pain, tenderness, or weakness; onset of abdominal pain; or any other new symptoms.
-Patients should be instructed to notify their healthcare provider of all medications, supplements, and herbal preparations they are taking.
-Patients should be instructed to talk to their health care provider if they are pregnant, planning to become pregnant, or breastfeeding; women should not breastfeed during treatment and for 5 days after the final dose.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.