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Emtricitabine Dosage

Applies to the following strength(s): 200 mg ; 10 mg/mL

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for HIV Infection

Capsules: 200 mg orally once a day
Oral solution: 240 mg (24 mL) orally once a day

Approved indication: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Usual Adult Dose for Occupational Exposure

(Not approved by FDA)

US Public Health Service working group recommendations:
Capsules: 200 mg orally once a day
Duration of therapy: 28 days, if tolerated

Comments:
-Emtricitabine plus tenofovir plus raltegravir is recommended as the preferred regimen for HIV postexposure prophylaxis; emtricitabine is also recommended as a component in various alternative regimens.
-Prophylaxis should be started as soon as possible, preferably within hours after exposure.
-The optimal duration of prophylaxis is unknown and may differ based on the institution's protocol.
-The most current therapeutic guidelines should be consulted for more information.

Usual Adult Dose for Nonoccupational Exposure

(Not approved by FDA)

CDC recommendations:
Capsules: 200 mg orally once a day
Duration of therapy: 28 days

Comments:
-Emtricitabine should be used in combination with efavirenz plus (tenofovir or zidovudine), or with lopinavir-ritonavir plus zidovudine.
-Prophylaxis should be started as soon as possible, within 72 hours of exposure.

Usual Pediatric Dose for HIV Infection

Oral solution:
0 to 3 months: 3 mg/kg orally once a day
3 months through 17 years: 6 mg/kg orally once a day
Maximum dose: 240 mg (24 mL)

Capsules:
3 months through 17 years, weighing more than 33 kg, and able to swallow intact capsule: 200 mg orally once a day

Approved indication: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

Renal Dose Adjustments

Adults:
Capsules:
CrCl 30 to 49 mL/min: 200 mg orally every 48 hours
CrCl 15 to 29 mL/min: 200 mg orally every 72 hours
CrCl less than 15 mL/min: 200 mg orally every 96 hours

Oral solution:
CrCl 30 to 49 mL/min: 120 mg orally every 24 hours
CrCl 15 to 29 mL/min: 80 mg orally every 24 hours
CrCl less than 15 mL/min: 60 mg orally every 24 hours

Comments:
-Safety and efficacy of these dosing guidelines have not been clinically evaluated.
-Clinical response to therapy and renal function should be closely monitored in these patients.

Pediatric patients: Insufficient data to recommend dose adjustments; however, dose reductions or increased intervals should be considered.

Liver Dose Adjustments

No adjustment recommended.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Hemodialysis:
Capsules: 200 mg orally every 96 hours
Oral Solution: 60 mg orally every 24 hours

Comments:
-Doses should be given after dialysis sessions when used on dialysis days.

Other Comments

Administration advice:
-May be taken without regard to food

Storage requirements:
-Oral solution: Should store refrigerated (2C to 8C [36F to 46F]); should not freeze
-Oral solution: May store at room temperature (25C [77F]; excursions permitted to 15C to 30C [59F to 86F]) for up to 3 months; should discard any remaining solution after the 3 months

General:
-Use of emtricitabine in therapy-experienced patients should be guided by laboratory testing and treatment history.

Monitoring:
-Hepatic: For chronic hepatitis B virus (HBV) in all patients (before therapy); hepatic function with clinical and laboratory follow-up in patients coinfected with HIV-1 and HBV (for at least several months after stopping therapy)
-Renal: Renal function with CrCl less than 50 mL/min

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