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Dextromethorphan / Guaifenesin / Phenylephrine Dosage

Applies to the following strength(s): 5 mg-50 mg-2.5 mg/5 mL ; 10 mg-200 mg-5 mg/5 mL ; 10 mg-100 mg-5 mg/5 mL ; 5 mg-100 mg-2.5 mg/2.5 mL ; 20 mg-200 mg-10 mg/10 mL ; 40 mg-200 mg-20 mg/10 mL ; 23 mg-600 mg-9 mg ; 14 mg-288 mg-7 mg ; 30 mg-600 mg-10 mg ; 25 mg-175 mg-12.5 mg/5 mL ; 30 mg-200 mg-10 mg/5 mL ; 5 mg-50 mg-2.5 mg/mL ; 30 mg-600 mg-15 mg ; 20 mg-200 mg-5 mg/5 mL ; 15 mg-350 mg-10 mg/5 mL ; 5 mg-100 mg-2.5 mg/mL ; 15 mg-100 mg-5 mg/5 mL ; 20 mg-100 mg-10 mg/5 mL ; 25 mg-600 mg-20 mg ; 30 mg-600 mg-20 mg ; 15 mg-395 mg-10 mg ; 15 mg-380 mg-10 mg ; 20 mg-400 mg-10 mg/20 mL ; 5 mg-100 mg-2.5 mg/5 mL ; 30 mg-900 mg-30 mg ; 15 mg-390 mg-10 mg ; 20 mg-1200 mg-40 mg ; 5 mg-75 mg-2.5 mg/5 mL ; 20 mg-400 mg-10 mg/5 mL ; 20 mg-400 mg-10 mg ; 28 mg-388 mg-10 mg/5 mL ; 7.5 mg-88 mg-2.5 mg/mL ; 15 mg-300 mg-10 mg/5 mL ; 29 mg-390 mg-10 mg/5 mL ; 28 mg-388 mg-10 mg ; 18 mg-200 mg-10 mg/15 mL ; 60 mg-600 mg-40 mg ; 25 mg-550 mg-20 mg ; 20 mg-800 mg-20 mg ; 30 mg-1200 mg-30 mg ; 10 mg-200 mg-5 mg ; 45 mg-1200 mg-25 mg ; 60 mg-1000 mg-40 mg ; 30 mg-1000 mg-20 mg ; 15 mg-350 mg-12 mg

The information at Drugs.com is not a substitute for medical advice. Always consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cough and Nasal Congestion

Dextromethorphan 15 mg/guaifenesin 100 mg/phenylephrine 5 mg/5 mL:
10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 15 mg/guaifenesin 300 mg/phenylephrine 10 mg/5 mL:
10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 20 mg/guaifenesin 100 mg/phenylephrine 10 mg/5 mL:
5 mL orally every 4 to 6 hours not to exceed 30 mL daily.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 5 mg/5 mL:
10 mL orally every 8 hours not to exceed 30 mL daily

Dextromethorphan 20 mg/guaifenesin 800 mg/phenylephrine 20 mg oral tablets, extended release:
1 to 1.5 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg oral tablets:
1 tablet orally every 4 hours not to exceed 6 tablets in 24 hours

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg /5 mL oral liquid:
5 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours

Dextromethorphan 30 mg/guaifenesin 900 mg/phenylephrine 30 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 25 mg/guaifenesin 175 mg/phenylephrine 12.5 mg/5 mL:
5 mL orally four times daily.

Dextromethorphan 25 mg/guaifenesin 550 mg/phenylephrine 20 mg oral tablets, and Dextromethorphan 25 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
1 to 2 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1000 mg/phenylephrine 20 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1200 mg/phenylephrine 30 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 10 mg oral tablets, extended release:
1 to 2 tablets orally every 12 hours not to exceed 4 tablets daily.

Dextromethorphan 40 mg/guaifenesin 200 mg/phenylephrine 20 mg/10 mL extended release suspension:
10 mL orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 45 mg/guaifenesin 1200 mg/phenylephrine 25 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 600 mg/phenylephrine 40 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 1000 mg/phenylephrine 40 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 20 mg/guaifenesin 800 mg/phenylephrine 20 mg oral tablets, extended release:
1 to 1.5 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
1 or 2 tablets orally twice a day not to exceed 2 doses daily.

Dextromethorphan/guaifenesin/phenylephrine 14 mg-288 mg-7 mg oral capsule:
1 capsule orally every 4 to 6 hours.

Dextromethorphan 15 mg/guaifenesin 380 mg/phenylephrine 10 mg oral capsule:
1 capsule orally every 4 hours not to exceed 6 tablets daily.

Dextromethorphan 20 mg/guaifenesin 400 mg/phenylephrine 10 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 4 tablets in 24 hours.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 10 mg/10 mL oral liquid:
1 prefilled spoon (10 mL) orally every 4 hours.

Dextromethorphan 5 mg/guaifenesin 50 mg/phenylephrine 2.5 mg/5 mL oral liquid:
20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 15 mg-350 mg-12 mg oral tablet:
1 tablet orally every 6 hours, not to exceed 4 tablets in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 10 mg-200 mg-5 mg/5 mL oral liquid:
10 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/5 mL oral liquid:
5 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 5 mg-75 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/20 mL oral liquid:
20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Usual Pediatric Dose for Cough and Nasal Congestion

Dextromethorphan 5 mg/guaifenesin 50 mg/phenylephrine 2.5 mg/5 mL oral liquid:
over 6 months to less than 9 months: 0.75 mL orally 4 times daily.
over 9 months to 18 months: 1 mL orally 4 times daily.

Dextromethorphan 15 mg/guaifenesin 100 mg/phenylephrine 5 mg/5 mL:
over 2 yrs to less than 6 yrs: 2.5 mL orally every 6 hours not to exceed 10 mL daily.
over 6 yrs to less than 12 yrs: 5 mL orally every 6 hours not to exceed 20 mL daily.
over 12 yrs: 10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 15 mg/guaifenesin 300 mg/phenylephrine 10 mg/5 mL:
over 6 yrs to less than 12 yrs: 5 mL orally every 6 hours not to exceed 20 mL daily.
over 12 yrs: 10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 20 mg/guaifenesin 100 mg/phenylephrine 10 mg/5 mL:
over 2 yrs to less than 6 yrs: 1.25 mL orally every 4 to 6 hours not to exceed 7.5 mL daily.
over 6 yrs to less than 12 yrs: 2.5 mL orally every 4 to 6 hours not to exceed 15 mL daily.
over 12 yrs: 5 mL orally every 4 to 6 hours not to exceed 30 mL daily.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 5 mg/5 mL:
over 2 yrs to less than 6 yrs: 2.5 mL orally every 8 hours not to exceed 7.5 mL daily.
over 6 yrs to less than 12 yrs: 5 mL orally every 8 hours not to exceed 15 mL daily.
over 12 yrs: 10 mL orally every 8 hours not to exceed 30 mL daily.

Dextromethorphan 25 mg/guaifenesin 175 mg/phenylephrine 12.5 mg/5 mL oral syrup:
over 2 yrs to less than 6 yrs: 1.25 mL orally four times daily.
over 6 yrs to less than 12 yrs: 2.5 mL orally four times daily.
over 12 yrs: 5 mL orally four times daily.

Dextromethorphan 23 mg/guaifenesin 600 mg/phenylephrine 9 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: one half tablet orally every 12 hours not to exceed 1 tablet daily
over 12 yrs: 1 or 2 tablets orally every 12 hours not to exceed 4 tablets daily.

Dextromethorphan 20 mg/guaifenesin 800 mg/phenylephrine 20 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 to 1.5 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 25 mg/guaifenesin 550 mg/phenylephrine 20 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 to 2 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 25 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
over 2 yrs to less than 6 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 6 yrs to less than 12 yrs: 1/2 to 1 tablet orally every 12 hours not to exceed 1 1/2 tablet daily.
over 12 yrs: 1 to 2 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1200 mg/phenylephrine 30 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 10 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1 tablet orally every 12 hours not to exceed 2 tablets daily.
over 12 yrs: 1 to 2 tablets orally every 12 hours not to exceed 4 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1000 mg/phenylephrine 20 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 40 mg/guaifenesin 200 mg/phenylephrine 20 mg/10 mL:
over 3 yrs to less than 6 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL daily.
over 6 yrs to less than 12 yrs: 5 mL orally every 12 hours not to exceed 10 mL daily.
over 12 yrs: 10 mL orally every 12 hours not to exceed 20 mL daily.

Dextromethorphan 45 mg/guaifenesin 1200 mg/phenylephrine 25 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 2 doses daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 600 mg/phenylephrine 40 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 2 doses daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 1000 mg/phenylephrine 40 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 2 doses daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 5 mg/guaifenesin 100 mg/phenylephrine 2.5 mg/5 mL:
over 2 yrs to less than 6 yrs and 11 kg to 21 kg: 2.5 mL orally every 4 hours not to exceed 15 mL daily.

Dextromethorphan 30 mg/guaifenesin 900 mg/phenylephrine 30 mg oral tablets, extended release:
6 years to 12 years: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
12 years or older: 1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
12 years or older: 1 or 2 tablets orally twice a day not to exceed 2 doses daily.

Dextromethorphan/guaifenesin/phenylephrine 14 mg-288 mg-7 mg oral capsule:
over 12 yrs: 1 capsule orally every 4 to 6 hours.

Dextromethorphan 15 mg/guaifenesin 380 mg/phenylephrine 10 mg oral capsule:
12 years or older: 1 capsule orally every 4 hours not to exceed 6 tablets daily.

Dextromethorphan 20 mg/guaifenesin 400 mg/phenylephrine 10 mg oral tablet:
6 years to 12 years: 1/2 tablet orally every 4 to 6 hours not to exceed 2 tablets in 24 hours.
over 12 yrs 1 tablet orally every 4 to 6 hours not to exceed 4 tablets in 24 hours.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 10 mg/10 mL oral liquid:
12 years or older: 1 prefilled spoon (10 mL) orally every 4 hours.

Dextromethorphan 5 mg/guaifenesin 50 mg/phenylephrine 2.5 mg/5 mL oral liquid:
4 years to 5 years: 5 mL orally every 4 hours not to exceed 6 doses in 24 hours.
6 years to 11 years: 10 mL orally every 4 hours not to exceed 6 doses in 24 hours.
12 years or older: 20 mL orally every 4 hours not to exceed 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 15 mg-350 mg-12 mg oral tablet:
12 years or older: 1 tablet orally every 6 hours, not to exceed 4 tablets in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 10 mg-200 mg-5 mg/5 mL oral liquid:
12 years or older: 10 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 5 mg-100 mg-2.5 mg/5 mL oral liquid:
4 years to 5 years: 5 mL orally every 4 hours not to exceed 6 doses in 24 hours.
6 years to 11 years: 10 mL orally every 4 hours not to exceed 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/5 mL oral liquid:
12 years or older: 5 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 5 mg-75 mg-2.5 mg/5 mL oral liquid:
2 years to 5 years: 5 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.
6 years to 11 years: 10 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.
12 years or older: 20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/20 mL oral liquid:
12 years or older: 20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg oral tablets:
Over 12 years of age: 1 tablet orally every 4 hours not to exceed 6 tablets in 24 hours
6 years to under 12 years of age: 1/2 tablet orally every 4 hours not to exceed 3 tablets in 24 hours

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg /5 mL oral liquid:
12 years and over: 5 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours
6 years to under 12 years of age: 2.5 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours
2 years to 6 years of age: 1.25 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours

Dextromethorphan 7.5 mg/guaifenesin 88 mg/phenylephrine 2.5 mg /1 mL oral liquid:
6 years to under 12 years of age: 2 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours
2 years to 6 years of age: 1 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

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