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Dextromethorphan / Guaifenesin / Phenylephrine Dosage

Medically reviewed on April 13, 2018.

Applies to the following strengths: 5 mg-50 mg-2.5 mg/5 mL; 10 mg-200 mg-5 mg/5 mL; 10 mg-100 mg-5 mg/5 mL; 5 mg-100 mg-2.5 mg/2.5 mL; 20 mg-200 mg-10 mg/10 mL; 40 mg-200 mg-20 mg/10 mL; 23 mg-600 mg-9 mg; 14 mg-288 mg-7 mg; 30 mg-600 mg-10 mg; 25 mg-175 mg-12.5 mg/5 mL; 30 mg-200 mg-10 mg/5 mL; 5 mg-50 mg-2.5 mg/mL; 20 mg-200 mg-5 mg/5 mL; 15 mg-350 mg-10 mg/5 mL; 5 mg-100 mg-2.5 mg/mL; 30 mg-600 mg-15 mg; 15 mg-100 mg-5 mg/5 mL; 20 mg-100 mg-10 mg/5 mL; 25 mg-600 mg-20 mg; 30 mg-600 mg-20 mg; 15 mg-395 mg-10 mg; 15 mg-380 mg-10 mg; 20 mg-400 mg-10 mg/20 mL; 5 mg-100 mg-2.5 mg/5 mL; 30 mg-900 mg-30 mg; 15 mg-390 mg-10 mg; 17.5 mg-385 mg-10 mg; 20 mg-1200 mg-40 mg; 5 mg-75 mg-2.5 mg/5 mL; 20 mg-400 mg-10 mg/5 mL; 20 mg-400 mg-10 mg; 28 mg-388 mg-10 mg/5 mL; 7.5 mg-88 mg-2.5 mg/mL; 15 mg-300 mg-10 mg/5 mL; 29 mg-390 mg-10 mg/5 mL; 28 mg-388 mg-10 mg; 9 mg-198 mg-5 mg; 18 mg-200 mg-10 mg/15 mL; 60 mg-600 mg-40 mg; 25 mg-550 mg-20 mg; 20 mg-800 mg-20 mg; 30 mg-1200 mg-30 mg; 10 mg-200 mg-5 mg; 45 mg-1200 mg-25 mg; 60 mg-1000 mg-40 mg; 30 mg-1000 mg-20 mg; 15 mg-350 mg-12 mg

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Cough and Nasal Congestion

Dextromethorphan 15 mg/guaifenesin 100 mg/phenylephrine 5 mg/5 mL:
10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 15 mg/guaifenesin 300 mg/phenylephrine 10 mg/5 mL:
10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 20 mg/guaifenesin 100 mg/phenylephrine 10 mg/5 mL:
5 mL orally every 4 to 6 hours not to exceed 30 mL daily.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 5 mg/5 mL:
10 mL orally every 8 hours not to exceed 30 mL daily

Dextromethorphan 20 mg/guaifenesin 800 mg/phenylephrine 20 mg oral tablets, extended release:
1 to 1.5 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg oral tablets:
1 tablet orally every 4 hours not to exceed 6 tablets in 24 hours

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg /5 mL oral liquid:
5 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours

Dextromethorphan 30 mg/guaifenesin 900 mg/phenylephrine 30 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 25 mg/guaifenesin 175 mg/phenylephrine 12.5 mg/5 mL:
5 mL orally four times daily.

Dextromethorphan 25 mg/guaifenesin 550 mg/phenylephrine 20 mg oral tablets, and Dextromethorphan 25 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
1 to 2 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1000 mg/phenylephrine 20 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1200 mg/phenylephrine 30 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 10 mg oral tablets, extended release:
1 to 2 tablets orally every 12 hours not to exceed 4 tablets daily.

Dextromethorphan 40 mg/guaifenesin 200 mg/phenylephrine 20 mg/10 mL extended release suspension:
10 mL orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 45 mg/guaifenesin 1200 mg/phenylephrine 25 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 600 mg/phenylephrine 40 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 1000 mg/phenylephrine 40 mg oral tablets, extended release:
1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 20 mg/guaifenesin 800 mg/phenylephrine 20 mg oral tablets, extended release:
1 to 1.5 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
1 or 2 tablets orally twice a day not to exceed 2 doses daily.

Dextromethorphan/guaifenesin/phenylephrine 14 mg-288 mg-7 mg oral capsule:
1 capsule orally every 4 to 6 hours.

Dextromethorphan 15 mg/guaifenesin 380 mg/phenylephrine 10 mg oral capsule:
1 capsule orally every 4 hours not to exceed 6 tablets daily.

Dextromethorphan 20 mg/guaifenesin 400 mg/phenylephrine 10 mg oral tablet:
1 tablet orally every 4 to 6 hours not to exceed 4 tablets in 24 hours.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 10 mg/10 mL oral liquid:
1 prefilled spoon (10 mL) orally every 4 hours.

Dextromethorphan 5 mg/guaifenesin 50 mg/phenylephrine 2.5 mg/5 mL oral liquid:
20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 15 mg-350 mg-12 mg oral tablet:
1 tablet orally every 6 hours, not to exceed 4 tablets in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 10 mg-200 mg-5 mg/5 mL oral liquid:
10 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/5 mL oral liquid:
5 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 5 mg-75 mg-2.5 mg/5 mL oral liquid:
20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/20 mL oral liquid:
20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Usual Pediatric Dose for Cough and Nasal Congestion

Dextromethorphan 5 mg/guaifenesin 50 mg/phenylephrine 2.5 mg/5 mL oral liquid:
over 6 months to less than 9 months: 0.75 mL orally 4 times daily.
over 9 months to 18 months: 1 mL orally 4 times daily.

Dextromethorphan 15 mg/guaifenesin 100 mg/phenylephrine 5 mg/5 mL:
over 2 yrs to less than 6 yrs: 2.5 mL orally every 6 hours not to exceed 10 mL daily.
over 6 yrs to less than 12 yrs: 5 mL orally every 6 hours not to exceed 20 mL daily.
over 12 yrs: 10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 15 mg/guaifenesin 300 mg/phenylephrine 10 mg/5 mL:
over 6 yrs to less than 12 yrs: 5 mL orally every 6 hours not to exceed 20 mL daily.
over 12 yrs: 10 mL orally every 6 hours not to exceed 40 mL daily.

Dextromethorphan 20 mg/guaifenesin 100 mg/phenylephrine 10 mg/5 mL:
over 2 yrs to less than 6 yrs: 1.25 mL orally every 4 to 6 hours not to exceed 7.5 mL daily.
over 6 yrs to less than 12 yrs: 2.5 mL orally every 4 to 6 hours not to exceed 15 mL daily.
over 12 yrs: 5 mL orally every 4 to 6 hours not to exceed 30 mL daily.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 5 mg/5 mL:
over 2 yrs to less than 6 yrs: 2.5 mL orally every 8 hours not to exceed 7.5 mL daily.
over 6 yrs to less than 12 yrs: 5 mL orally every 8 hours not to exceed 15 mL daily.
over 12 yrs: 10 mL orally every 8 hours not to exceed 30 mL daily.

Dextromethorphan 25 mg/guaifenesin 175 mg/phenylephrine 12.5 mg/5 mL oral syrup:
over 2 yrs to less than 6 yrs: 1.25 mL orally four times daily.
over 6 yrs to less than 12 yrs: 2.5 mL orally four times daily.
over 12 yrs: 5 mL orally four times daily.

Dextromethorphan 23 mg/guaifenesin 600 mg/phenylephrine 9 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: one half tablet orally every 12 hours not to exceed 1 tablet daily
over 12 yrs: 1 or 2 tablets orally every 12 hours not to exceed 4 tablets daily.

Dextromethorphan 20 mg/guaifenesin 800 mg/phenylephrine 20 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 to 1.5 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 25 mg/guaifenesin 550 mg/phenylephrine 20 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 to 2 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 25 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
over 2 yrs to less than 6 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 6 yrs to less than 12 yrs: 1/2 to 1 tablet orally every 12 hours not to exceed 1 1/2 tablet daily.
over 12 yrs: 1 to 2 tablets orally every 12 hours not to exceed 3 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1200 mg/phenylephrine 30 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 10 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1 tablet orally every 12 hours not to exceed 2 tablets daily.
over 12 yrs: 1 to 2 tablets orally every 12 hours not to exceed 4 tablets daily.

Dextromethorphan 30 mg/guaifenesin 1000 mg/phenylephrine 20 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 40 mg/guaifenesin 200 mg/phenylephrine 20 mg/10 mL:
over 3 yrs to less than 6 yrs: 2.5 mL orally every 12 hours not to exceed 5 mL daily.
over 6 yrs to less than 12 yrs: 5 mL orally every 12 hours not to exceed 10 mL daily.
over 12 yrs: 10 mL orally every 12 hours not to exceed 20 mL daily.

Dextromethorphan 45 mg/guaifenesin 1200 mg/phenylephrine 25 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 2 doses daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 600 mg/phenylephrine 40 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 2 doses daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 60 mg/guaifenesin 1000 mg/phenylephrine 40 mg oral tablets, extended release:
over 6 yrs to less than 12 yrs: 1/2 tablet orally every 12 hours not to exceed 2 doses daily.
over 12 yrs: 1 tablet orally every 12 hours not to exceed 2 doses daily.

Dextromethorphan 5 mg/guaifenesin 100 mg/phenylephrine 2.5 mg/5 mL:
over 2 yrs to less than 6 yrs and 11 kg to 21 kg: 2.5 mL orally every 4 hours not to exceed 15 mL daily.

Dextromethorphan 30 mg/guaifenesin 900 mg/phenylephrine 30 mg oral tablets, extended release:
6 years to 12 years: 1/2 tablet orally every 12 hours not to exceed 1 tablet daily.
12 years or older: 1 tablet orally every 12 hours not to exceed 2 tablets daily.

Dextromethorphan 30 mg/guaifenesin 600 mg/phenylephrine 20 mg oral tablets, extended release:
12 years or older: 1 or 2 tablets orally twice a day not to exceed 2 doses daily.

Dextromethorphan/guaifenesin/phenylephrine 14 mg-288 mg-7 mg oral capsule:
over 12 yrs: 1 capsule orally every 4 to 6 hours.

Dextromethorphan 15 mg/guaifenesin 380 mg/phenylephrine 10 mg oral capsule:
12 years or older: 1 capsule orally every 4 hours not to exceed 6 tablets daily.

Dextromethorphan 20 mg/guaifenesin 400 mg/phenylephrine 10 mg oral tablet:
6 years to 12 years: 1/2 tablet orally every 4 to 6 hours not to exceed 2 tablets in 24 hours.
over 12 yrs 1 tablet orally every 4 to 6 hours not to exceed 4 tablets in 24 hours.

Dextromethorphan 20 mg/guaifenesin 200 mg/phenylephrine 10 mg/10 mL oral liquid:
12 years or older: 1 prefilled spoon (10 mL) orally every 4 hours.

Dextromethorphan 5 mg/guaifenesin 50 mg/phenylephrine 2.5 mg/5 mL oral liquid:
4 years to 5 years: 5 mL orally every 4 hours not to exceed 6 doses in 24 hours.
6 years to 11 years: 10 mL orally every 4 hours not to exceed 6 doses in 24 hours.
12 years or older: 20 mL orally every 4 hours not to exceed 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 15 mg-350 mg-12 mg oral tablet:
12 years or older: 1 tablet orally every 6 hours, not to exceed 4 tablets in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 10 mg-200 mg-5 mg/5 mL oral liquid:
12 years or older: 10 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 5 mg-100 mg-2.5 mg/5 mL oral liquid:
4 years to 5 years: 5 mL orally every 4 hours not to exceed 6 doses in 24 hours.
6 years to 11 years: 10 mL orally every 4 hours not to exceed 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/5 mL oral liquid:
12 years or older: 5 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 5 mg-75 mg-2.5 mg/5 mL oral liquid:
2 years to 5 years: 5 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.
6 years to 11 years: 10 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.
12 years or older: 20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan/guaifenesin/phenylephrine 20 mg-400 mg-10 mg/20 mL oral liquid:
12 years or older: 20 mL orally every 4 hours. Do not take more than 6 doses in 24 hours.

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg oral tablets:
Over 12 years of age: 1 tablet orally every 4 hours not to exceed 6 tablets in 24 hours
6 years to under 12 years of age: 1/2 tablet orally every 4 hours not to exceed 3 tablets in 24 hours

Dextromethorphan 28 mg/guaifenesin 388 mg/phenylephrine 10 mg /5 mL oral liquid:
12 years and over: 5 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours
6 years to under 12 years of age: 2.5 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours
2 years to 6 years of age: 1.25 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours

Dextromethorphan 7.5 mg/guaifenesin 88 mg/phenylephrine 2.5 mg /1 mL oral liquid:
6 years to under 12 years of age: 2 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours
2 years to 6 years of age: 1 mL orally every 6 to 8 hours not to exceed 4 doses 24 hours

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dialysis

Data not available

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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