Skip to Content

Dextromethorphan / guaifenesin / phenylephrine Drug Interactions

A total of 849 drugs are known to interact with dextromethorphan / guaifenesin / phenylephrine.

  • 219 major drug interactions
  • 625 moderate drug interactions
  • 5 minor drug interactions

Show all medications in the database that may interact with dextromethorphan / guaifenesin / phenylephrine.

Check for interactions

Type in a drug name to check for interactions with dextromethorphan / guaifenesin / phenylephrine.

Most frequently checked interactions

View interaction reports for dextromethorphan / guaifenesin / phenylephrine and the medicines listed below.

  • acetaminophen / dextromethorphan (Triaminic Cough & Sore Throat, Tylenol Cough and Sore Throat Daytime, Vicks DayQuil HBP Cold & Flu, Tylenol Children’s Cold + Cough + Sore Throat, PediaCare Cough & Sore Throat Plus Acetaminophen, Drixoral Cough/Sore Throat, Triaminic Softchews Cough & Sore Throat, Children's Triacting, Tylenol Cold & Cough Daytime, Topcare Cough and Sore Throat)
  • acetaminophen / dextromethorphan / guaifenesin / phenylephrine (Tylenol Cold & Flu Severe, Cough & Cold Relief, Vicks DayQuil Severe Cold & Flu, Mucinex Children's Multi-Symptom Cold & Fever, Sudafed PE Cold & Cough, Mucinex Fast-Max Day Time Severe Cold, Mucinex Children's Cold, Cough & Sore Throat, Mucinex Fast-Max Cold, Flu & Sore Throat Liquid Gels, Mucinex Fast-Max Cold, Flu & Sore Throat, Decorel Forte Plus, Robitussin Severe Multi-Symptom Cough Cold + Flu, Tylenol Cold Multi-Symptom Severe, Cold & Cough PE Multi-Symptom, Delsym Cough+ Cold Day Time, Mucinex Fast-Max Severe Cold, Non-Pseudo Cold Relief, Tylenol Cold + Mucus Severe, CounterAct Day, Tylenol Cold Head Congestion Severe (old formulation), Mucinex Fast-Max Severe Congestion & Cold, Alka-Seltzer Plus Severe Cough, Mucus & Congestion Liquid Gels, Alka-Seltzer Plus Severe Sinus, Cold & Cough Liquid Gels, Phenflu DM, Alka-Seltzer Plus Severe Cold, Mucus & Congestion, Alka-Seltzer Plus Day Severe Cold+Flu Hot Drink Mix, Cold Head Congestion, Cold Multi-Symptom Severe, ConRx Cold, Adult Cold, Flu & Sore Throat, Mucus Relief Complete, Mucus Relief Plus, Suphedrine PE Cold & Cough, Sudafed PE Pressure+Pain+Cold, Tylenol Cough & Severe Congestion Daytime)
  • Adderall (amphetamine / dextroamphetamine)
  • Azithromycin Dose Pack (azithromycin)
  • Benadryl (diphenhydramine)
  • Celebrex (celecoxib)
  • Clarinex (desloratadine)
  • Flexeril (cyclobenzaprine)
  • guaifenesin / phenylephrine (Deconex, Gilphex TR, Reluri, Aldex, Xpect-PE, Triaminic Chest & Nasal Congestion, Mydex, Nazarin, Mucus Relief Sinus, Chest Congestion Relief PE, Mucus Relief PE, Efasin, Endal, Prolex D, Crantex, Pendex, Wellbid-D, Guaiphen-D 600, Guaiphen-D 1200, Donatussin Drops, Simuc, Zotex GPX, Duomax, Guaifen PE, Norel EX, Aldex G, Nexphen PD, Nariz, Duraphen 1000, Lusonex, Dynex LA, Miraphen PE, Sudex, Extendryl G, Rescon-GG, Maxiphen, Entex LA, Guaphenyl LA, MontePhen, Gentex LA, Xedec II, Liquibid-D, Simuc-GP, Zotex-GP, Duratuss PE, Sitrex PD, Refenesen Chest Congestion Relief PE, Medent-PE, Genexa LA, Ambi 40/1000, J-Max, Medent-PEI, D-Phen 1000, Mucinex Children's Stuffy Nose & Cold, Visonex, Deconex IR, Guiadex PD, Guiatex PE, Entex LQ, Aquatab D, Respa-PE, Sudafed PE Non-Drying Sinus, Liquibid D-R, Liquibid PD-R, Relcof IR, Lusair, D-Tab, ExeTuss, ExeTuss-GP, MucaphEd, Fenesin PE IR, Reese Onetab Congestion & Cough, Nu-COPD, Supress-PE, Dimetapp Children's Cold & Chest Congestion, Zyrphen, PE-Guai, Tussi-Pres PE, Sinupan, Deconsal Pediatric, Amidal, Chemdal, Quindal, SINUvent PE, Crantex LA Capsules, Amitex LA, Entex ER, Duraphen II, Liquibid-PD, Crantex ER, Liquibid-D 1200, Phenavent LA, Quintex, Phenavent D, Deconsal II, Guaifed Caps, Guaifed PD, Sina-12X, Phenavent, Tussbid, Phenavent PED, Nescon-PD, Prolex PD, Duravent PE, Nasex, Crantex LA Tablets, ED Bron GP, Duratuss, Duratuss GP, Sitrex, Guaiphen-PD, Wellbid-D 1200, Despec, Xedec, Nasex-G)
  • Medrol Dosepak (methylprednisolone)
  • MS Contin (morphine)
  • Mucinex DM (dextromethorphan / guaifenesin)
  • Nasonex (mometasone nasal)
  • Norco (acetaminophen / hydrocodone)
  • Norvasc (amlodipine)
  • Prozac (fluoxetine)
  • Reglan (metoclopramide)
  • Singulair (montelukast)
  • Toprol-XL (metoprolol)
  • Tums Regular Strength (calcium carbonate)
  • Ventolin HFA (albuterol)
  • Vitamin C (ascorbic acid)
  • Vitamin D2 (ergocalciferol)

Dextromethorphan / guaifenesin / phenylephrine alcohol/food interactions

There is 1 alcohol/food interaction with dextromethorphan / guaifenesin / phenylephrine

Dextromethorphan / guaifenesin / phenylephrine disease interactions

There are 5 disease interactions with dextromethorphan / guaifenesin / phenylephrine which include:

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.