Atzumi Dosage

Generic name: DIHYDROERGOTAMINE MESYLATE 5.2mg
Dosage form: nasal powder
Drug class: Antimigraine agents

Medically reviewed by Drugs.com. Last updated on May 8, 2025.

Dosing Information

ATZUMI is for nasal administration only.

The recommended dose of ATZUMI is 5.2 mg (the contents of one nasal device) and is administered as a powdered medicine into one nostril.

The dose may be repeated, if needed, a minimum of 1 hour after the first dose. The maximum dose in a 24-hour period is 10.4 mg (two doses of ATZUMI 5.2 mg). The safety of taking more than 4 doses in a 7-day period or 12 doses within a 30-day period has not been established.

Assessment Prior to First Dose

Prior to initiation of ATZUMI, a cardiovascular evaluation is recommended. For patients with risk factors predictive of coronary artery disease who are determined to have a satisfactory cardiovascular evaluation, it is strongly recommended that administration of the first dose of ATZUMI take place in the setting of an equipped healthcare facility.

Administration Instructions

Priming is not required.
To administer a dose of ATZUMI, remove the round blue tab from the blue nozzle, and insert the blue nozzle into one nostril.  Squeeze the white air pump 3 separate times into 1 nostril while inhaling.  Allow the white air pump to expand back to its original shape between squeezes.
Fast, complete, pulse-like squeezes are needed to deliver the complete dose. Do not squeeze slowly, partially or with any hesitation.