Trovafloxacin Disease Interactions
There are 3 disease interactions with trovafloxacin:
Quinolones (Includes Trovafloxacin) ↔ Myasthenia Gravis
Severe Potential Hazard, Moderate plausibility
Applies to: Myasthenia Gravis
Fluoroquinolones have neuromuscular blocking activity and may exacerbate muscle weakness in persons with myasthenia gravis. Postmarketing serious adverse events, including deaths and requirement for ventilatory support, have been associated with fluoroquinolones use in persons with myasthenia gravis. Fluoroquinolones should be avoided in patients with history of myasthenia gravis.
Quinolones (Includes Trovafloxacin) ↔ Tendonitis
Severe Potential Hazard, Moderate plausibility
Applies to: Tendonitis
Tendonitis and ruptures of the shoulder, hand, and Achilles tendons have been reported in patients receiving quinolones, both during and after treatment. Therapy with quinolones should be administered cautiously in patients with preexisting tendonitis, since it may delay the recognition or confound the diagnosis of a quinolone-induced musculoskeletal effect. It is recommended to discontinue these agents if, at any time during therapy, pain, inflammation or rupture of a tendon develop and institute appropriate therapy.
- "Product Information. Penetrex (enoxacin)." Rhone-Poulenc Rorer, Collegeville, PA.
- "Product Information. Factive (gemifloxacin)." GeneSoft Inc, San Francisco, CA.
- "Product Information. Zagam (sparfloxacin)." Rhone-Poulenc Rorer, Collegeville, PA.
Trovafloxacin (Includes Trovafloxacin) ↔ Liver Disease
Severe Potential Hazard, High plausibility
Applies to: Liver Disease, Biliary Obstruction
Trovafloxacin undergoes metabolism by the liver as well as excretion by the hepatobiliary system. Patients with hepatic impairment or biliary obstruction may be at greater risk for adverse effects from trovafloxacin due to decreased drug clearance. Therapy with trovafloxacin should be administered cautiously in these patients. The manufacturer recommends a dosage reduction in mild to moderate cirrhosis. Periodic assessment of hepatic function is advised, especially during prolonged therapy (>= 21 days), since trovafloxacin can also cause elevations of liver enzymes.
- Teng R, Harris SC, Nix DE, Schentag JJ, Foulds G, Liston TE "Pharmacokinetics and safety of trovafloxacin (CP-99,219), a new quinolone antibiotic, following administration of single oral dose to healthy male volunteers." J Antimicrob Chemother 36 (1995): 385-94
- Dalvie DK, Khosla N, Vincent J "Excretion and metabolism of trovafloxacin in humans." Drug Metab Dispos 25 (1997): 423-7
- "Product Information. Trovan (trovafloxacin)." Pfizer US Pharmaceuticals, New York, NY.
trovafloxacin drug Interactions
There are 424 drug interactions with trovafloxacin
trovafloxacin alcohol/food Interactions
There are 2 alcohol/food interactions with trovafloxacin
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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