Bridion Disease Interactions
There are 3 disease interactions with Bridion (sugammadex).
Sugammadex (applies to Bridion) bleeding
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Coagulation Defect
Sugammadex increases the risk of coagulopathies and bleeding. It is recommended to carefully monitor coagulation parameters in patients with known coagulopathies being treated with therapeutic anticoagulation, receiving thromboprophylaxis drugs, other than heparin and low molecular weight heparin.
Sugammadex (applies to Bridion) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Sugammadex is not metabolized nor excreted by the liver. It is recommended to use caution when administering sugammadex to patients with hepatic impairment as no dedicated trials have been conducted in these patients.
Sugammadex (applies to Bridion) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
Sugammadex is substantially excreted by the kidney, and the risk of toxic reactions to this drug may be higher in patients with impaired renal function. Dosage adjustment is not required in patients with mild to moderate renal impairment. Sugammadex is not recommended for use in patients with severe renal impairment, including those requiring dialysis, due to insufficient safety information combined with the prolonged and increased overall exposure in these patients.
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Bridion drug interactions
There are 28 drug interactions with Bridion (sugammadex).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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