Silodosin Disease Interactions
There are 3 disease interactions with silodosin:
Silodosin (Includes silodosin) ↔ hepatic impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Liver Disease
The use of silodosin is contraindicated in patients with severe hepatic impairment. No dosage adjustment is needed in patients with mild or moderate hepatic impairment.
Silodosin (Includes silodosin) ↔ severe renal impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
The use of silodosin is contraindicated in patients with severe renal impairment (CrCl < 30 mL/min). Caution and regular monitoring is recommended in patients with moderate renal impairment as the plasma concentrations can increase three times higher when compared with subjects with normal renal function. Dose should be reduced to 4 mg/day in patients with moderate renal impairment.
Antiadrenergic agents (Includes silodosin) ↔ cataracts
Moderate Potential Hazard, Moderate plausibility. Applies to: Cataracts
Intraoperative Floppy Iris Syndrome has been observed during cataract surgery in some patients on or previously treated with antiadrenergic agents. If a patient is undergoing cataract surgery, the ophthalmologist should be prepared for possible modifications of the surgical technique (iris hooks, iris dilator rings). There does not appear to be a benefit in stopping antiadrenergic agents therapy prior to the cataracts surgery.
Silodosin drug interactions
There are 571 drug interactions with silodosin
Silodosin alcohol/food interactions
There are 2 alcohol/food interactions with silodosin
More about silodosin
- Silodosin Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Support Group
- En Español
- 101 Reviews
- Drug class: antiadrenergic agents, peripherally acting
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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