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Riluzole Disease Interactions

There are 4 disease interactions with riluzole.

Moderate

Riluzole (applies to riluzole) alcohol

Moderate Potential Hazard, High plausibility. Applicable conditions: Alcoholism

Alcohol consumption may intensify the hepatotoxic potential of riluzole. Therefore, patients should be warned to limit alcohol intake while receiving riluzole therapy.

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Moderate

Riluzole (applies to riluzole) liver disease

Moderate Potential Hazard, High plausibility.

The use of riluzole has been frequently associated with an increase in liver enzymes between 3 and 5 times the upper limit of normal (ULN). Therapy with riluzole should be administered cautiously in patients with a history of liver dysfunction. Baseline liver function tests (LFTs) should be obtained in all patients. Monitor patients for signs and symptoms of hepatic injury, every month for the first 3 months of treatment, and periodically thereafter. The use of riluzole is not recommended if patients develop hepatic transaminases levels greater than 5 times the ULN. Discontinue riluzole if there is evidence of liver dysfunction (e.g., elevated bilirubin). Patients with mild or moderate [Child-Pugh score A and B] hepatic impairment had increases in AUC compared to patients with normal hepatic function, and may be at increased risk of adverse reactions. The impact of severe hepatic impairment on riluzole exposure is unknown.

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Moderate

Riluzole (applies to riluzole) neutropenia

Moderate Potential Hazard, Moderate plausibility.

The use of riluzole has rarely been associated with neutropenia with an absolute neutrophil count (ANC) less than 500/mm3. The neutropenia developed within the first 2 months of treatment. Therapy with riluzole should be administered cautiously in patients predisposed to neutropenia. Patients should be warned to report any febrile illness.

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Moderate

Riluzole (applies to riluzole) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Riluzole and its metabolites are eliminated via the kidney. Therapy with riluzole should be administered cautiously in patients with renal dysfunction. Reduced clearance and higher plasma levels may occur in these patients. Women, native Japanese patients, and the elderly may metabolize or excrete riluzole at a slower rate. The need for dosage adjustment is not known.

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Riluzole drug interactions

There are 67 drug interactions with riluzole.

Riluzole alcohol/food interactions

There is 1 alcohol/food interaction with riluzole.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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