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Daraprim (pyrimethamine) Disease Interactions

There is 1 disease interaction with Daraprim (pyrimethamine):


Pyrimethamine (Includes Daraprim) ↔ folate deficiency

Severe Potential Hazard, High plausibility. Applies to: Malabsorption Syndrome, Acute Alcohol Intoxication, Anemia Associated with Folate Deficiency

Pyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.


  1. "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome, Research Triangle Park, NC.

Daraprim (pyrimethamine) drug interactions

There are 71 drug interactions with Daraprim (pyrimethamine)

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.