Daraprim (pyrimethamine) Disease Interactions
There is 1 disease interaction with Daraprim (pyrimethamine):
Pyrimethamine (Includes Daraprim) ↔ Folate Deficiency
Severe Potential Hazard, High plausibility
Applies to: Malabsorption Syndrome, Acute Alcohol Intoxication, Anemia Associated with Folate Deficiency
Pyrimethamine is a folate antagonist. The use of pyrimethamine is contraindicated in patients with megaloblastic anemia caused by folate deficiency. Pyrimethamine should be used with caution in patients with malabsorption syndrome, alcoholism, pregnancy, and in those receiving other folate depleting drugs. Monitoring CBCs and platelet counts are recommended. If signs of folic acid deficiency occur, the drug dosage should be reduced or discontinued. Leucovorin may need to be administered to reverse folic acid deficiency.
- "Product Information. Daraprim (pyrimethamine)." Glaxo Wellcome, Research Triangle Park, NC.
Daraprim (pyrimethamine) drug Interactions
There are 72 drug interactions with Daraprim (pyrimethamine)
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- Drug class: miscellaneous antimalarials
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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