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Adagen (pegademase bovine) Disease Interactions

There are 2 disease interactions with Adagen (pegademase bovine):


Pegademase bovine (applies to Adagen) bone marrow transplantation

Major Potential Hazard, Moderate plausibility.

The use of pegademase bovine is contraindicated as preparatory or support therapy for bone marrow transplantation.


Pegademase bovine (applies to Adagen) platelet disorders

Major Potential Hazard, Moderate plausibility. Applicable conditions: Thrombocytopenia, Coagulation Defect, Thrombocytopathy

Pegademase bovine should be used with caution in patients with thrombocytopenia. This agent should not be used in patients with severe thrombocytopenia. Pegademase is administered by IM injection and the risk of bleeding is increased in the presence of severe thrombocytopenia. Therapy with pegademase bovine should be administered cautiously in patients with coagulation or platelet function disorders.

Adagen (pegademase bovine) drug interactions

There are 2 drug interactions with Adagen (pegademase bovine)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.