Skip to Content

Adagen Side Effects

Generic Name: pegademase bovine

Note: This document contains side effect information about pegademase bovine. Some of the dosage forms listed on this page may not apply to the brand name Adagen.

For the Consumer

Applies to pegademase bovine: intramuscular solution

Along with its needed effects, pegademase bovine (the active ingredient contained in Adagen) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pegademase bovine:

Incidence not known
  • Back, leg, or stomach pains
  • bleeding gums
  • chills
  • dark urine
  • difficulty breathing
  • dizziness
  • fever
  • general body swelling
  • headache
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pain, warmth, or burning in the fingers, toes, and legs
  • pale skin
  • problems with vision or hearing
  • sore throat
  • unusual tiredness or weakness
  • yellowing of the eyes or skin

Some side effects of pegademase bovine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Hives or welts
  • itching
  • redness of skin
  • redness or pain at the site of injection
  • skin rash

For Healthcare Professionals

Applies to pegademase bovine: intramuscular solution


Rare (less than 0.1%): Antibody development


Postmarketing reports: Hemolytic anemia, autoimmune hemolytic anemia, thrombocythemia, thrombocytopenia, autoimmune thrombocytopenia[Ref]


Postmarketing reports: Lymphomas


Postmarketing reports: Urticaria[Ref]

Nervous system

Frequency not reported: Headache[Ref]


Frequency not reported: Injection site pain, injection site erythema


1. "Product Information. Adagen (pegademase bovine)." Enzon Inc, Piscataway, NJ.

Some side effects of Adagen may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.