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Adagen Side Effects

Generic name: pegademase bovine

Medically reviewed by Last updated on Sep 9, 2023.

Note: This document contains side effect information about pegademase bovine. Some dosage forms listed on this page may not apply to the brand name Adagen.

Applies to pegademase bovine: intramuscular solution.

Serious side effects of Adagen

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your child's doctor or get medical help right away if your child has any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Other side effects of Adagen

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your child's doctor or get medical help if your child has any side effects that bother your child or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your child's doctor. Call your child's doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to pegademase bovine: intramuscular solution.


Rare (less than 0.1%): Antibody development


Postmarketing reports: Hemolytic anemia, autoimmune hemolytic anemia, thrombocythemia, thrombocytopenia, autoimmune thrombocytopenia[Ref]


Postmarketing reports: Lymphomas


Postmarketing reports: Urticaria[Ref]

Nervous system

Frequency not reported: Headache[Ref]


Frequency not reported: Injection site pain, injection site erythema


1. Product Information. Adagen (pegademase bovine). Enzon Inc. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.