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Adagen Side Effects

Generic Name: pegademase bovine

Note: This page contains information about the side effects of pegademase bovine. Some of the dosage forms included on this document may not apply to the brand name Adagen.

For the Consumer

Applies to pegademase bovine: intramuscular solution

In addition to its needed effects, some unwanted effects may be caused by pegademase bovine (the active ingredient contained in Adagen). In the event that any of these side effects do occur, they may require medical attention.

Major Side Effects

You should check with your doctor immediately if any of these side effects occur when taking pegademase bovine:

Incidence not known:
  • Back, leg, or stomach pains
  • bleeding gums
  • chills
  • dark urine
  • difficulty breathing
  • dizziness
  • fever
  • general body swelling
  • headache
  • loss of appetite
  • nausea or vomiting
  • nosebleeds
  • pain, warmth, or burning in the fingers, toes, and legs
  • pale skin
  • problems with vision or hearing
  • sore throat
  • unusual tiredness or weakness
  • yellowing of the eyes or skin

Minor Side Effects

Some of the side effects that can occur with pegademase bovine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Incidence not known:
  • Hives or welts
  • itching
  • redness of skin
  • redness or pain at the site of injection
  • skin rash

For Healthcare Professionals

Applies to pegademase bovine: intramuscular solution


Rare (less than 0.1%): Antibody development


Postmarketing reports: Hemolytic anemia, autoimmune hemolytic anemia, thrombocythemia, thrombocytopenia, autoimmune thrombocytopenia[Ref]


Postmarketing reports: Lymphomas


Postmarketing reports: Urticaria[Ref]

Nervous system

Frequency not reported: Headache[Ref]


Frequency not reported: Injection site pain, injection site erythema


1. "Product Information. Adagen (pegademase bovine)." Enzon Inc, Piscataway, NJ.

Not all side effects for Adagen may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.