Miconazole Disease Interactions
There are 2 disease interactions with miconazole:
Miconazole (Includes Miconazole) ↔ Liver Disease
Moderate Potential Hazard, Moderate plausibility
Applies to: Liver Disease
The use of miconazole in patients with liver disease has not been adequately studied, although it is known that miconazole is primarily metabolized by the liver. Therapy with miconazole should be administered cautiously in patients with liver disease, and the dosing adjusted or discontinued according to clinical response.
- "Product Information. Monistat (miconazole)." Ortho Pharmaceutical Corporation, Raritan, NJ.
- Lewi PJ, Boelaert J, Daneels R, et al "Pharmacokinetic profile of intravenous miconazole in man." Eur J Clin Pharmacol 10 (1976): 49-54
- Daneshmend TK, Warnock DW "Clinical pharmacokinetics of systemic antifungal drugs." Clin Pharmacokinet 8 (1983): 17-42
Miconazole (Includes Miconazole) ↔ Hyperlipidemia
Minor Potential Hazard, Moderate plausibility
Applies to: Hyperlipidemia
Elevations in cholesterol and triglyceride levels may occur in patients receiving intravenous miconazole and are attributed to the drug vehicle, Cremophor EL (polyethoxylated castor oil). These increases are reversible upon discontinuation of miconazole therapy. Clinicians should be cognizant of these effects when interpreting lab results of hyperlipidemic patients during treatment with miconazole.
- Rose HD, Roth DA, Barboriak JJ "Hyperlipidemia related to miconazole therapy." Ann Intern Med 91 (1979): 491-2
- Heel RC, Brogden RN, Pakes GE, Speight TM, Avery GS "Miconazole: a preliminary review of its therapeutic efficacy in systemic fungal infections." Drugs 19 (1980): 7-30
- Naito HK, McHenry MC, Lewis LA "Drug-induced dyslipoproteinemia: a report of two cases." Clin Chem 26 (1980): 163-8
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miconazole drug Interactions
There are 352 drug interactions with miconazole
miconazole alcohol/food Interactions
There is 1 alcohol/food interaction with miconazole
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
|Major||Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderate||Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minor||Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
Do not stop taking any medications without consulting your healthcare provider.
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