Lasmiditan Disease Interactions
There are 4 disease interactions with lasmiditan:
Lasmiditan (Includes lasmiditan) ↔ hepatic dysfunction
Major Potential Hazard, Moderate plausibility. Applies to: Liver Disease
The use of lasmiditan is not recommended in patients with severe hepatic impairment. No dosage adjustment is needed for patients with mild or moderate hepatic impairment.
Lasmiditan (Includes lasmiditan) ↔ CNS depression
Moderate Potential Hazard, Moderate plausibility. Applies to: Altered Consciousness, Alcoholism
The use of lasmiditan may cause central nervous system (CNS) depression, including dizziness and sedation. Because of the potential for lasmiditan to cause sedation, other cognitive or neuropsychiatric adverse reactions, and driving impairment, this agent should be used with caution if used in combination with alcohol or other CNS depressants. It is recommended to evaluate patients for risk of CNS depression and patients should be warned against engaging in potentially hazardous activities requiring complete mental alertness, such as driving a motor vehicle or operating machinery, for at least 8 hours after lasmiditan is taken. Patients who cannot follow this recommendation should not take lasmiditan.
Lasmiditan (Includes lasmiditan) ↔ drug abuse
Moderate Potential Hazard, Moderate plausibility. Applies to: Drug Abuse/Dependence
The use of lasmiditan has the potential to cause abuse. It is recommended to evaluate patients for risk of drug abuse and observe them for signs of lasmiditan misuse or abuse. Drug dependence was not observed in healthy subjects following abrupt cessation after 7 daily doses of lasmiditan 200 mg or 400 mg.
Lasmiditan (Includes lasmiditan) ↔ serotonin syndrome
Moderate Potential Hazard, Moderate plausibility. Applies to: CNS Disorder
The use of lasmiditan has been associated with reactions consistent with serotonin syndrome. Serotonin syndrome may also occur with lasmiditan during coadministration with serotonergic drugs. The onset of symptoms usually occurs within minutes to hours of receiving a new or a greater dose of a serotonergic medication. It is recommended to discontinue therapy if serotonin syndrome is suspected.
Lasmiditan drug interactions
There are 435 drug interactions with lasmiditan
More about lasmiditan
- Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- 5 Reviews
- Drug class: antimigraine agents
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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