Leqvio Disease Interactions
There are 2 disease interactions with Leqvio (inclisiran).
Moderate
Inclisiran (applies to Leqvio) liver dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease
Inclisiran has not been studied in patients with severe liver dysfunction; caution is recommended. No dose adjustments are needed for patients with mild to moderate liver dysfunction.
Moderate
Inclisiran (applies to Leqvio) renal dysfunction
Moderate Potential Hazard, Moderate plausibility.
Inclisiran has not been studied in patients with end-stage renal disease; caution is recommended. No dose adjustments are needed for patients with mild, moderate, or severe renal dysfunction.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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