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Inavolisib Disease Interactions

There are 3 disease interactions with inavolisib.

Moderate

Inavolisib (applies to inavolisib) diabetes

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus

Treatment with inavolisib may cause severe hyperglycemia. The safety of inavolisib in patients with type 1 diabetes mellitus or type 2 diabetes mellitus requiring ongoing antihyperglycemic treatment have not been studied. Patients with a history of well-controlled type 2 diabetes mellitus may require intensified antihyperglycemic treatment and close monitoring of fasting glucose levels.

Moderate

Inavolisib (applies to inavolisib) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Inavolisib has not been studied in patients with moderate to severe hepatic impairment.

Moderate

Inavolisib (applies to inavolisib) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Use of inavolisib has not been evaluated in patients with severe renal impairment (estimated GFR less than 30 mL/min). Dose reduction is recommended in patients with moderate renal impairment (estimated GFR 30 to less than 60 mL/min) due to significantly increased exposure.

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Inavolisib drug interactions

There are 218 drug interactions with inavolisib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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