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Inavolisib Disease Interactions

There are 3 disease interactions with inavolisib.

Moderate

Inavolisib (applies to inavolisib) diabetes

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Diabetes Mellitus

Treatment with inavolisib may cause severe hyperglycemia. The safety of inavolisib in patients with type 1 diabetes mellitus or type 2 diabetes mellitus requiring ongoing antihyperglycemic treatment have not been studied. Patients with a history of well-controlled type 2 diabetes mellitus may require intensified antihyperglycemic treatment and close monitoring of fasting glucose levels.

References (1)
  1. (2024) "Product Information. Itovebi (inavolisib)." Genentech
Moderate

Inavolisib (applies to inavolisib) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Inavolisib has not been studied in patients with moderate to severe hepatic impairment.

References (1)
  1. (2024) "Product Information. Itovebi (inavolisib)." Genentech
Moderate

Inavolisib (applies to inavolisib) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Use of inavolisib has not been evaluated in patients with severe renal impairment (estimated GFR less than 30 mL/min). Dose reduction is recommended in patients with moderate renal impairment (estimated GFR 30 to less than 60 mL/min) due to significantly increased exposure.

References (1)
  1. (2024) "Product Information. Itovebi (inavolisib)." Genentech

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Inavolisib drug interactions

There are 218 drug interactions with inavolisib.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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