Inavolisib Side Effects
Medically reviewed by Drugs.com. Last updated on Dec 10, 2024.
Applies to inavolisib: oral tablet.
Important warnings
This medicine can cause some serious health issues
Use only as directed.
Tell your doctor if you use other medicines or have other medical conditions or allergies.
Get emergency medical help if you have signs of an allergic reaction: hives, difficult breathing, swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
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high blood sugar--increased thirst, increased urination, dry mouth, fruity breath odor;
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blurred vision;
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confusion;
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weight loss, increased appetite;
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severe diarrhea, blood in your stools, stomach pain; or
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blisters or ulcers in your mouth, red or swollen gums, trouble swallowing.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
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abnormal lab results;
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loss of appetite;
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rash;
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feeling weak or tired;
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nausea; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
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For healthcare professionals
Applies to inavolisib: oral tablet.
General adverse events
The most common adverse reactions occurring in at least 20% of patients included decreased neutrophils, decreased hemoglobin, increased fasting glucose, decreased platelets, decreased lymphocytes, stomatitis, diarrhea, decreased calcium, fatigue, decreased potassium, increased creatinine, increased ALT, nausea, decreased sodium, decreased magnesium, rash, decreased appetite, COVID-19 infection, and headache.[Ref]
Dermatologic
- Very common (10% or more): Rash (26%), alopecia (19%), dry skin/fissures/xerosis/xeroderma (13%)
Endocrine
- Very common (10% or more): Increased fasting glucose levels (85%)
Gastrointestinal
- Very common (10% or more): Stomatitis (51%), diarrhea (48%), nausea (28%), increased lipase (16%), vomiting (15%)
- Frequency not reported: Abdominal pain, dysgeusia, dyspepsia
Stomatitis included aphthous ulcer, glossitis, glossodynia, lip ulceration, mouth ulceration, and mucosal inflammation.
Hematologic
- Very common (10% or more): Decreased total and absolute neutrophils (95%), decreased hemoglobin (88%), decreased platelets (84%), decreased absolute lymphocytes (72%)
Hepatic
- Very common (10% or more): Increased ALT (34%)
Metabolic
- Very common (10% or more): Decreased appetite (24%), decreased calcium (42%), decreased potassium (38%), decreased sodium (28%), decreased magnesium (27%)
Nervous system
- Very common (10% or more): Headache (22%)
Ocular
- Frequency not reported: Dry eye
Other
- Very common (10% or more): Fatigue (38%), COVID-19 infection (23%), decreased weight (17%)
Renal
- Very common (10% or more): Increased creatinine (38%), urinary tract infection (15%)
References
1. (2024) "Product Information. Itovebi (inavolisib)." Genentech
More about inavolisib
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Further information
Inavolisib side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.