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Filgrastim Disease Interactions

There are 3 disease interactions with filgrastim:

Major

Csf (Includes Filgrastim) ↔ Glomerulonephritis

Severe Potential Hazard, Moderate plausibility

Applies to: Renal Dysfunction

Although it has been reported that renal dysfunction has no effect on the pharmacokinetics of colony stimulating factors (CSF), filgrastim and pegfilgrastim may cause glomerulonephritis. Symptoms include swelling of the face or ankles, dark colored urine, or blood in the urine, or a decrease in urine production. Advise patients to report signs or symptoms of glomerulonephritis immediately. Monitoring of patients with renal dysfunction is recommended.

Major

Csf (Includes Filgrastim) ↔ Myeloid Tumors

Severe Potential Hazard, Moderate plausibility

Applies to: Myeloproliferative Disorders

Colony stimulating factors primarily stimulates the proliferation of neutrophils but may also, theoretically, enhance tumor growth, particularly in myeloid malignancies. Therapy with these drugs should be administered cautiously in patients with myeloid tumors. Additionally, if used for PBPC (peripheral blood progenitor cell) collection in such patients, tumor cells may be released from the marrow and collected in the leukapheresis product. The effect of reinfusion of tumor cells is uncertain at this time.

References

  1. "Product Information. Neupogen (filgrastim)." Amgen, Thousand Oaks, CA.
Major

Csf- Leukocytosis

Severe Potential Hazard, Moderate plausibility

Applies to: Leukocytosis

Filgrastim and pegfilgrastim are growth factors for neutrophil progenitor cells. Therefore, these should not be used in patients with leukocytosis. If excessive white blood cell counts occur during CSF therapy, treatment should be interrupted or the dosage reduced.

References

  1. Hollingshead LM, Goa KL "Recombinant granulocyte colony-stimulating factor (rG-CSF). A review of its pharmacological properties and prospective role in neutropenic conditions." Drugs 42 (1991): 300-30
  2. "Product Information. Neupogen (filgrastim)." Amgen, Thousand Oaks, CA.

filgrastim drug Interactions

There are 119 drug interactions with filgrastim

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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