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Famciclovir Disease Interactions

There are 2 disease interactions with famciclovir:

Major

Famciclovir (applies to famciclovir) renal dysfunction

Major Potential Hazard, High plausibility.

Penciclovir, the active antiviral metabolite of famciclovir, is primarily eliminated by the kidney. Acute renal failure has been reported in patients with underlying renal disease who did not receive an appropriate dosage reduction. Dosage adjustments are recommended for patients with moderate to severe renal impairment (CrCl < 60 mL/min).

References

  1. Gill KS, Wood MJ "The clinical pharmacokinetics of famciclovir." Clin Pharmacokinet 31 (1996): 1-8
  2. "Product Information. Famvir (famciclovir)." SmithKline Beecham, Philadelphia, PA.
  3. Boike SC, Pue MA, Freed MI, Audet PR, Fairless A, Ilson BE, Zariffa N, Jorkasky DK "Pharmacokinetics of famciclovir in subjects with varying degrees of renal impairment." Clin Pharmacol Ther 55 (1994): 418-26
Moderate

Famciclovir (applies to famciclovir) liver disease

Moderate Potential Hazard, Moderate plausibility.

Famciclovir is converted by the liver to the active antiviral metabolite, penciclovir. The bioavailability of penciclovir following a dose of famciclovir was not affected in patients with well-compensated chronic liver disease. However, there are no data on the pharmacokinetic disposition of famciclovir in patients with severe uncompensated liver disease. Therapy with famciclovir should be administered cautiously in these patients, since the clinical significance of possible famciclovir accumulation is unknown. Theoretically, famciclovir may also not be effective in these patients.

References

  1. "Product Information. Famvir (famciclovir)." SmithKline Beecham, Philadelphia, PA.
  2. Perry CM, Wagstaff AJ "Famciclovir - a review of its pharmacological properties and therapeutic efficacy in herpesvirus infections." Drugs 50 (1995): 396-415
  3. Boike SC, Pue M, Audet PR, Freed MI, Fairless A, Ilson BE, Zariffa N, Jorkasky DK "Pharmacokinetics of famciclovir in subjects with chronic hepatic disease." J Clin Pharmacol 34 (1994): 1199-207
  4. Gill KS, Wood MJ "The clinical pharmacokinetics of famciclovir." Clin Pharmacokinet 31 (1996): 1-8
View all 4 references

Famciclovir drug interactions

There are 8 drug interactions with famciclovir

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.