Ertugliflozin / sitagliptin Disease Interactions
There are 3 disease interactions with ertugliflozin / sitagliptin:
DPP-4 inhibitors (Includes ertugliflozin/sitagliptin) ↔ pancreatitis
Severe Potential Hazard, Low plausibility. Applies to: Pancreatitis
There have been postmarketing reports of acute pancreatitis in patients taking DPP-4 inhibitors. These drugs should be used with caution in patients with a history of pancreatitis or pancreatic disease, although it is unknown if they are at increased risk. Patients should be observed for signs and symptoms of pancreatitis during treatment. If pancreatitis is suspected, treatment should be discontinued immediately and appropriate management should be initiated.
Ertugliflozin (Includes ertugliflozin/sitagliptin) ↔ renal impairment
Severe Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction
The use of ertugliflozin is contraindicated in patients with severe renal impairment, end-stage renal disease, or dialysis. The use of ertugliflozin in patients with moderate renal impairment did not have improvement in glycemic control, and had increased risks for renal impairment, renal-related adverse reactions and volume depletion adverse reactions; therefore, its use is not recommended in this population. No dosage adjustment or increased monitoring is needed in patients with mild renal impairment. Renal function should be evaluated prior to initiating treatment with ertugliflozin and periodically thereafter.
DPP-4 (Includes ertugliflozin/sitagliptin) ↔ renal dysfunction
Moderate Potential Hazard, High plausibility. Applies to: Renal Dysfunction
It is recommended to assess renal function prior to initiating treatment with DPP-4 inhibitors. Patients with moderate to severe renal insufficiency and end stage renal dysfunction will require a dose adjustment. Linagliptin will not require a dose adjustment per manufacturer's information. Additionally, there have been postmarketing reports of worsening renal function in some patients with renal insufficiency taking sitagliptin at inappropriate doses. However, sitagliptin has not been found to be nephrotoxic in preclinical studies or clinical trials at appropriate doses.
Ertugliflozin / sitagliptin drug interactions
There are 671 drug interactions with ertugliflozin / sitagliptin
Ertugliflozin / sitagliptin alcohol/food interactions
There is 1 alcohol/food interaction with ertugliflozin / sitagliptin
More about ertugliflozin/sitagliptin
- Ertugliflozin/sitagliptin Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- En Español
- Drug class: antidiabetic combinations
- FDA Alerts (4)
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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