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Droxidopa Disease Interactions

There are 2 disease interactions with droxidopa:


Droxidopa (Includes droxidopa) ↔ ischemic heart disease/arrhythmias/CHF

Moderate Potential Hazard, High plausibility. Applies to: Ischemic Heart Disease, Congestive Heart Failure, Arrhythmias, Hypertension

Droxidopa is directly metabolized in vivo to norepinephrine via decarboxylation. As such, it may exacerbate certain cardiovascular conditions by increasing blood pressure and heart rate. Therapy with droxidopa should be considered cautiously in patients with ischemic heart disease, arrhythmias, or congestive heart failure. Additionally, droxidopa may exacerbate supine hypertension in patients with neurogenic orthostatic hypotension. Patients should be advised to elevate the head of the bed while resting or sleeping. Blood pressure should be monitored both in supine position and the head- elevated sleeping position. If hypertension persists, then droxidopa dosage should be reduced or discontinued. If hypertension is not well managed, it can increase the risk of cardiovascular events, especially stroke.


Droxidopa (Includes droxidopa) ↔ renal impairment

Moderate Potential Hazard, Moderate plausibility. Applies to: Renal Dysfunction

Droxidopa and its metabolites is primarily cleared by the kidneys. Patients with mild and moderate renal impairment did not show adverse reactions in clinical trials. However, the clinical experience in patients with severe renal function (GFR < 30 mL/min) is limited. Caution is advised in patients with severe renal impairment.

Droxidopa drug interactions

There are 358 drug interactions with droxidopa

Droxidopa alcohol/food interactions

There is 1 alcohol/food interaction with droxidopa

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.