Zonalon Disease Interactions
There are 2 disease interactions with Zonalon (doxepin topical).
Doxepin topical (applies to Zonalon) anticholinergic effects
Moderate Potential Hazard, High plausibility. Applicable conditions: Glaucoma/Intraocular Hypertension, Urinary Retention, Gastrointestinal Obstruction, Dementia
Doxepin possesses anticholinergic activity and is systemically absorbed when applied topically. Therapy with doxepin should be administered cautiously in patients with conditions adversely affected by anticholinergic activity, such as urinary retention, angle-closure glaucoma or elevated intraocular pressure, gastrointestinal obstructive disorders, or dementia.
Doxepin topical (applies to Zonalon) renal/hepatic dysfunction
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease
Doxepin topical is systemically absorbed and metabolized by the liver to an active form. Parent drug and metabolites are eliminated by the kidney. Renal and hepatic impairment alter the metabolism and elimination of doxepin and/or its metabolites.
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Zonalon drug interactions
There are 589 drug interactions with Zonalon (doxepin topical).
Zonalon alcohol/food interactions
There is 1 alcohol/food interaction with Zonalon (doxepin topical).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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