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Proglycem (diazoxide) Disease Interactions

There are 5 disease interactions with Proglycem (diazoxide):

Moderate

Diazoxide (applies to Proglycem) arrhythmias

Moderate Potential Hazard, High plausibility.

The use of diazoxide is associated with compensatory tachycardia. Therapy with diazoxide should be administered cautiously in patients with tachycardia.

References

  1. "Product Information. Hyperstat I.V. (diazoxide)." Schering Corp, Kenilworth, NJ.
Moderate

Diazoxide (applies to Proglycem) congestive heart failure

Moderate Potential Hazard, High plausibility. Applicable conditions: Fluid Retention

Diazoxide may lead to significant fluid retention, which may precipitate congestive heart failure in patients with impaired cardiac reserve. The fluid retention will respond to conventional therapy with diuretics. Therapy with diazoxide should be administered cautiously in patients with congestive heart failure.

References

  1. "Product Information. Hyperstat I.V. (diazoxide)." Schering Corp, Kenilworth, NJ.
Moderate

Diazoxide (applies to Proglycem) gout

Moderate Potential Hazard, Moderate plausibility.

Diazoxide can increase serum uric acid levels due to decreased excretion. This should be kept in mind, particularly in patients with hyperuricemia or a history of gout.

Moderate

Diazoxide (applies to Proglycem) pulmonary hypertension

Moderate Potential Hazard, Moderate plausibility.

There have been postmarketing reports of pulmonary hypertension in infants and neonates treated with diazoxide. The cases were reversible upon discontinuation of the drug. Patients should be carefully monitored, especially those with risk factors for pulmonary hypertension, or respiratory distress. Diazoxide should be discontinued if pulmonary hypertension is suspected.

References

  1. "Product Information. Hyperstat I.V. (diazoxide)." Schering Corp, Kenilworth, NJ.
Moderate

Diazoxide (applies to Proglycem) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

The plasma half-life of diazoxide is prolonged in patients with impaired renal function. A reduced dosage should be considered. Serum electrolyte levels should also be evaluated for such patients. Caution and monitoring is advised.

Proglycem (diazoxide) drug interactions

There are 212 drug interactions with Proglycem (diazoxide)

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.