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Daptomycin Disease Interactions

There is 1 disease interaction with daptomycin.


Daptomycin (applies to daptomycin) renal dysfunction

Moderate Potential Hazard, Moderate plausibility.

Renal function tests and CPK should be monitored frequently in patients with renal impairment that are in treatment with daptomycin. Additionally, the success rates of treatment with this drug were lower when used in patients with CrCl <50 mL/min. This should be taken into account when selecting an antibacterial therapy in patients with baseline moderate to severe renal impairment.


  1. (2003) "Product Information. Cubicin (daptomycin)." Cubist Pharmaceuticals Inc

Daptomycin drug interactions

There are 59 drug interactions with daptomycin.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.