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Cannabidiol Disease Interactions

There are 2 disease interactions with cannabidiol.


Antiepileptics (applies to cannabidiol) suicidal tendency

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Depression, Psychosis

Antiepileptic drugs (AEDs) have been associated with an increased risk of suicidal thoughts or behavior in patients taking these drugs for any indication. Pooled analyses of 199 placebo-controlled clinical studies involving the use of 11 different AEDs showed that patients receiving AEDs had approximately twice the risk of suicidal thinking or behavior compared to patients receiving placebo. AEDs should be administered cautiously in patients with depression or other psychiatric disorders; phentermine-topiramate should be avoided in patients with history of suicidal attempts or active suicidal ideation. The risk of suicidal thoughts and behavior should be carefully assessed against the risk of untreated illness, bearing in mind that epilepsy and many other conditions for which AEDs are prescribed are themselves associated with morbidity and mortality and an increased risk of suicidal thoughts and behavior. Patients, caregivers, and families should be alert to the emergence or worsening of signs and symptoms of depression, any unusual changes in mood or behavior, or the emergence of suicidal thoughts or behavior. If patients have symptoms of suicidal ideation or behavior, a dosage reduction or treatment discontinuation should be considered.


  1. "Product Information. Tegretol (carbamazepine)." Novartis Pharmaceuticals (2002):
  2. "Product Information. Klonopin (clonazepam)." Roche Laboratories (2001):
  3. "Product Information. Dilantin (phenytoin)." Parke-Davis (2001):
  4. "Product Information. Cerebyx (fosphenytoin)." Parke-Davis (2001):
  5. "Product Information. Mysoline (primidone)." Elan Pharmaceuticals (2001):
  6. "Product Information. Lyrica (pregabalin)." Pfizer U.S. Pharmaceuticals Group (2005):
  7. "Product Information. Sabril (vigabatrin)." Lundbeck Inc (2009):
  8. "Product Information. Potiga (ezogabine)." GlaxoSmithKline (2011):
  9. "Product Information. Fycompa (perampanel)." Eisai Inc (2012):
  10. "Product Information. Briviact (brivaracetam)." UCB Pharma Inc (2016):
  11. "Product Information. Epidiolex (cannabidiol)." Greenwich Biosciences LLC (2018):
  12. "Product Information. Xcopri (cenobamate)." SK Life Science, Inc. (2020):
  13. "Product Information. Fintepla (fenfluramine)." Zogenix, Inc (2020):
  14. "Product Information. Ztalmy (ganaxolone)." Marinus Pharmaceuticals, Inc (2022):
  15. "Product Information. Diacomit (stiripentol)." Biocodex USA (2022):
  16. "Product Information. Qsymia (phentermine-topiramate)." Vivus Inc (2023):
  17. "Product Information. Topamax (topiramate)." Janssen Pharmaceuticals (2023):
View all 17 references

Cannabidiol (applies to cannabidiol) hepatic impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Liver Disease

Because of the risk of hepatocellular injury, serum transaminases (ALT and AST) and total bilirubin levels should be measured in all patients prior to starting treatment with cannabidiol. Cannabidiol causes dose-related elevations of liver transaminases, and in controlled studies 13% of patients receiving treatment had elevations above 3 times the ULN. Caution and monitoring is advised in patients with hepatic impairment, which can be at increased risk. Dose adjustment is recommended in patients with moderate (Child-Pugh B) hepatic impairment or severe (Child-Pugh C) hepatic impairment. It may be necessary to have slower dose titration in patients with moderate or severe hepatic impairment than in patients without hepatic impairment. If a patient develops clinical signs or symptoms suggestive of hepatic dysfunction (e.g., unexplained nausea, vomiting, right upper quadrant abdominal pain, fatigue, anorexia, or jaundice and/or dark urine), promptly measure serum transaminases and total bilirubin and interrupt or discontinue treatment with cannabidiol, as appropriate.


  1. "Product Information. Epidiolex (cannabidiol)." Greenwich Biosciences LLC (2018):

Cannabidiol drug interactions

There are 585 drug interactions with cannabidiol.

Cannabidiol alcohol/food interactions

There are 2 alcohol/food interactions with cannabidiol.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.