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Bimzelx Disease Interactions

There are 4 disease interactions with Bimzelx (bimekizumab).

Moderate

Bimekizumab (applies to Bimzelx) liver disease

Moderate Potential Hazard, Moderate plausibility.

Bimekizumab can cause increased levels of liver enzymes and bilirubin. Treatment with bimekizumab should be avoided in patients with acute liver disease or cirrhosis as they may be at increased risk for severe hepatic injury.

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Moderate

Bimekizumab (applies to Bimzelx) active Inflammatory Bowel Disease (IBD)

Moderate Potential Hazard, Moderate plausibility.

Cases of Inflammatory Bowel Disease (IBD) have been reported in patients treated with bimekizumab. Treatment with bimekizumab should be avoided in patients with active IBD.

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Moderate

Bimekizumab (applies to Bimzelx) depression/suicidal ideation

Moderate Potential Hazard, Moderate plausibility.

Patients with a history of suicidal ideation or behavior reported a higher rate of new onset of suicidal ideation when treated with bimekizumab. Patients with a history of severe depression are also susceptible to suicidal ideation or behavior when treated with bimekizumab.

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Moderate

Bimekizumab (applies to Bimzelx) infections

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Infection - Bacterial/Fungal/Protozoal/Viral

Bimekizumab may increase the risk of infections, including tuberculosis (TB). Patients should be evaluated for any active infection before and during treatment with bimekizumab, and administration should be avoided if infection is detected. Evaluate patients for TB before treatment and avoid therapy in patients with active TB. Anti-TB therapy should be considered for patients with a history of latent or active TB.

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Bimzelx drug interactions

There are 306 drug interactions with Bimzelx (bimekizumab).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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