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Vagisil Disease Interactions

There are 2 disease interactions with Vagisil (benzocaine / resorcinol topical).


Benzocaine (applies to Vagisil) methemoglobinemia

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency

Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.


  1. (2001) "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health
  2. (2001) "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals

Resorcinol topical (applies to Vagisil) hypothyroidism

Moderate Potential Hazard, Moderate plausibility.

The use of resorcinol topical has been associated with producing goiter in patients with abraded skin. Therapy with resorcinol topical should be administered cautiously in patients with hypothyroidism. Monitoring thyroid function is recommended in these patients.


  1. (2022) "Product Information. Resorcinol (resorcinol topical)." Apothecon Inc

Vagisil drug interactions

There are 53 drug interactions with Vagisil (benzocaine / resorcinol topical).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.