Benzocaine / dextromethorphan Disease Interactions
There are 2 disease interactions with benzocaine / dextromethorphan:
Antitussives (applies to benzocaine/dextromethorphan) psychiatric conditions
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Depression, Psychosis, Parkinsonism
Caution should be used when prescribing antitussives such as dextromethorphan and benzonatate in patients with psychiatric or emotional conditions. Isolated instances of bizarre behavior, including mental confusion and visual hallucinations have been reported in patients taking antitussives, specially when combined with other prescribed drugs such as monoamine oxidase inhibitors.
Benzocaine (applies to benzocaine/dextromethorphan) methemoglobinemia
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: G-6-PD Deficiency
Rarely, benzocaine has induced methemoglobinemia resulting in respiratory distress and cyanosis. Therapy with benzocaine should be administered cautiously to patients with or predisposed to methemoglobinemia. If life-threatening or severe methemoglobinemia develops, methylene blue infused at a dosage of 1 to 2 mg/kg body weight will rapidly reverse or improve the condition except in G-6-PD-deficient patients.
- "Product Information. Americaine (benzocaine topical)." Novartis Consumer Health, Summit, NJ.
- "Product Information. Americaine Otic (benzocaine otic)." Medeva Pharmaceuticals, Rochester, NY.
Benzocaine / dextromethorphan drug interactions
There are 315 drug interactions with benzocaine / dextromethorphan
Benzocaine / dextromethorphan alcohol/food interactions
There is 1 alcohol/food interaction with benzocaine / dextromethorphan
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
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