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Artemether / lumefantrine Disease Interactions

There are 2 disease interactions with artemether / lumefantrine:

Major

Antimalarial agents (applies to artemether/lumefantrine) QT prolongation

Major Potential Hazard, Moderate plausibility. Applicable conditions: Magnesium Imbalance, Hypokalemia, Arrhythmias

The use of certain antimalarial agents is contraindicated in patients with known prolongation of QT interval as they can develop fatal arrhythmias. It should also be avoided in patients with clinical conditions known to prolong the QT interval, such as a congenital prolongation of the QT interval or sudden death, uncorrected hypokalemia or hypomagnesemia, bradycardia, and certain cardiac conditions. Caution is advised in patients taking other medications that can prolong the QT interval.

References

  1. "Product Information. Quinine (quinine)." Zenith Goldline Pharmaceuticals, Fort Lauderdale, FL.
Moderate

Artemether (applies to artemether/lumefantrine) hepato/renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction, Liver Disease

The pharmacokinetics of artemether have not been studied in patients with either hepatic or renal impairment. Additionally, the efficacy and safety of the drug has not been studied in patients with severe hepatic and/or renal impairment. No dose adjustment is recommended for patients with renal impairment as there is no or insignificant renal excretion of lumefantrine, artemether and dihydroartemisinin (DHA), an active antimalarial metabolite of artemether. No dosage adjustment is necessary in patients with mild to moderate hepatic impairment. Caution should be exercised when administering lumefantrine and artemether to patients with severe hepatic or renal impairment. Close monitoring is recommended.

Artemether / lumefantrine drug interactions

There are 339 drug interactions with artemether / lumefantrine

Artemether / lumefantrine alcohol/food interactions

There is 1 alcohol/food interaction with artemether / lumefantrine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.