Medically reviewed by Drugs.com. Last updated on Apr 15, 2022.
Clostridioides difficile associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including lincomycin, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.Because lincomycin therapy has been associated with severe colitis which may end fatally, it should be reserved for serious infections where less toxic antimicrobials agents are inappropriate. It should not be used in patients with nonbacterial infections such as most upper respiratory tract infections.C difficile produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C difficile, and surgical evaluation should be instituted as clinically indicated .
Commonly used brand name(s)
In the U.S.
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Therapeutic Class: Antibiotic
Chemical Class: Lincosamide
Uses for lincomycin
Lincomycin injection treats bacterial infections. It may be also given to patients who have an allergic reaction to penicillin antibiotics.
Lincomycin belongs to the family of medicines called antibiotics. It works by killing bacteria or preventing their growth. However, lincomycin will not work for colds, flu, or other virus infections.
Lincomycin is to be given only by or under the direct supervision of your doctor.
Before using lincomycin
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For lincomycin, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to lincomycin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of lincomycin injection in children younger than 1 month of age. Safety and efficacy have not been established.
No information is available on the relationship of age to the effects of lincomycin injection in geriatric patients.
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Interactions with medicines
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving lincomycin, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using lincomycin with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Ascorbic Acid
- Cholera Vaccine, Live
Interactions with food/tobacco/alcohol
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other medical problems
The presence of other medical problems may affect the use of lincomycin. Make sure you tell your doctor if you have any other medical problems, especially:
- Allergy, history of or
- Asthma, history of or
- Diarrhea or
- Stomach or bowel disease (eg, colitis), history of or—Use with caution. May make these conditions worse.
- Kidney disease, severe or
- Liver disease, severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
Proper use of lincomycin
A nurse or other trained health professional will give you or your child lincomycin. Lincomycin is given as a shot into a muscle, vein or eye.
Precautions while using lincomycin
It is very important that your doctor check your or your child's progress while you are receiving lincomycin. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood and urine tests may be needed to check for unwanted effects.
Do not use lincomycin together with erythromycin (Ery-Tab®).
Lincomycin may cause serious allergic reactions, including anaphylaxis, which can be life-threatening and require immediate medical attention. Call your doctor right away if you or your child have a rash, itching, hives, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after you receive lincomycin.
Lincomycin injection may cause diarrhea, and in some cases it can be severe. It may occur 2 months or more after you stop using lincomycin. Do not take any medicine to treat diarrhea without first checking with your doctor. Diarrhea medicines may make the diarrhea worse or make it last longer. If you have any questions about this or if mild diarrhea continues or gets worse, check with your doctor.
Lincomycin side effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Incidence not known
- Abdominal or stomach pain or tenderness
- black, tarry stools
- blistering, peeling, or loosening of the skin
- blurred vision
- clay-colored stools
- dark urine
- difficulty with swallowing
- dizziness dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- fast heartbeat
- hives, itching, or rash
- joint or muscle pain
- loss of appetite
- lower back or side pain
- painful or difficult urination
- pale skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- red skin lesions, often with a purple center
- red, irritated eyes
- severe abdominal or stomach cramps and pain
- sore throat
- sores, ulcers, or white spots in the mouth or on the lips
- tightness in the chest
- ulcers, sores, or white spots in the mouth
- unpleasant breath odor
- unusual bleeding or bruising
- unusual tiredness or weakness
- vomiting of blood
- watery and severe diarrhea, which may also be bloody
- yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
- Abdominal or stomach discomfort
- continuing ringing or buzzing or other unexplained noise in the ears
- feeling of constant movement of self or surroundings
- hearing loss
- pain, redness, or hard lumps at the injection site
- redness, swelling, or soreness of the tongue
- sensation of spinning
- sleepiness or unusual drowsiness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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