Phentolamine Alternatives Compared

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Phentolamine	Phenoxybenzamine	Propranolol	Enter another drug to compare

Phentolamine

Phenoxybenzamine

Propranolol

Prescription only

Prescribed for Dermal Necrosis - Treatment, Pheochromocytoma, Reversal of Anesthesia, Pheochromocytoma Diagnosis. Phentolamine may also be used for purposes not listed in this medication guide.

Prescription only

Prescribed for Pheochromocytoma. Phenoxybenzamine may also be used for purposes not listed in this medication guide.

Prescription only

Propranolol is mainly used for blood pressure and angina control; however, it also has a role in migraine prevention and the treatment of essential tremor. Propranolol may cause vivid dreams and is... View more

More about Phentolamine

More about Phenoxybenzamine

More about Propranolol

Ratings & Reviews

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Propranolol has an average rating of 8.2 out of 10 from a total of 1378 ratings on Drugs.com. 77% of reviewers reported a positive effect, while 12% reported a negative effect.

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Side Effects Experienced by Users Side effects are reported in Drugs.com user reviews and not clinically verified.

View all Phentolamine side effects

View all Phenoxybenzamine side effects

Tremors (10.4%)
Anxiety (6.7%)
Tiredness (6.6%)
Increased heart rate (6.5%)
Dizziness (5.2%)
Sweating (4.9%)
Headaches (4.1%)

View all Propranolol side effects

Drug Class

Miscellaneous cardiovascular agents

Miscellaneous cardiovascular agents

Generic Availability

Lower cost generic

Pricing and Coupons * Prices are without insurance

Quantity	1 powder for injection
Strength	5 mg
Per unit^*	$362.63 - $421.57
Cost^*	$362.63 - $421.57

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Quantity	100 capsule
Strength	10 mg
Per unit^*	$38.93
Cost^*	$3,893.36

View all Phenoxybenzamine prices

Quantity	50 each
Strength	20 mg
Per unit^*	$0.35
Cost^*	$17.39

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Dosage Forms

Injectable powder for injection

Oral capsule

Intravenous solution
Oral capsule, extended release
Oral solution
Oral tablet

Half Life Drug half-life is the time required for plasma concentration to reduce to half its original value.

1 hour

24 hours

6.4 hours

CSA Schedule ¹ View glossary of CSA terms

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Category C Risk cannot be ruled out

See the full pregnancy warnings document.

Drug Interactions

A total of 219 drugs are known to interact with Phentolamine:

8 major drug interactions (21 brand and generic names)
186 moderate drug interactions (854 brand and generic names)
25 minor drug interactions (97 brand and generic names)

A total of 207 drugs are known to interact with Phenoxybenzamine:

8 major drug interactions (21 brand and generic names)
197 moderate drug interactions (844 brand and generic names)
2 minor drug interactions (4 brand and generic names)

A total of 590 drugs are known to interact with Propranolol:

47 major drug interactions (215 brand and generic names)
493 moderate drug interactions (3297 brand and generic names)
50 minor drug interactions (611 brand and generic names)

Alcohol/Food/Lifestyle Interactions

Phentolamine and alcohol may have additive effects in lowering your blood pressure. You may... View more

Phenoxybenzamine and alcohol may have additive effects in lowering your blood pressure. You may... View more

Food can enhance the levels of propranolol in your body. You shoud take propranolol at the same... View more

Disease Interactions

First Approval Date

January 30, 1952

January 26, 1953

November 13, 1967

WADA Class View classifications

N/A

P1 - Beta-Blockers

More Information

Patient Resources

Professional Resources

¹ The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer

Phentolamine Alternatives Compared

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