Skip to Content

Phentolamine Disease Interactions

There are 3 disease interactions with phentolamine:

Major

Phentolamine (applies to phentolamine) cardiovascular dysfunction

Major Potential Hazard, High plausibility. Applicable conditions: Ischemic Heart Disease, Arrhythmias

The use of phentolamine is contraindicated in patients with myocardial infarction, or a history of myocardial infarction, coronary artery disease or insufficiency, or angina. Hypotension due to decreased peripheral vascular resistance results from direct relaxation of vascular smooth muscle and/or alpha adrenergic blockade. Heart rate and cardiac output are increased due to beta adrenergic agonist properties. Acute and prolonged hypotensive episodes with reflex tachycardia and arrhythmia have also occurred during phentolamine therapy.

References

  1. Gould L, Reddy CV, Oh KC, Kim SG, Becker W "The effect of phentolamine on intra-Hisian conduction." J Electrocardiol 11 (1978): 391-4
  2. "Product Information. Regitine (phentolamine)." Ciba Pharmaceuticals, Summit, NJ.
  3. Gould L, Reddy CV, Gomprecht RF "The effect of phentolamine on conduction in the bundle of His." Angiology 26 (1975): 507-10
Moderate

Phentolamine (applies to phentolamine) cerebrovascular disorders

Moderate Potential Hazard, High plausibility. Applicable conditions: Cerebral Vascular Disorder

Cerebrovascular spasms and occlusions have occurred as a result of marked hypotension during phentolamine therapy. Therapy with phentolamine should be administered cautiously in patients with or a history of cerebrovascular disorders.

References

  1. "Product Information. Regitine (phentolamine)." Ciba Pharmaceuticals, Summit, NJ.
Moderate

Phentolamine (applies to phentolamine) hepatic/renal dysfunction

Moderate Potential Hazard, Low plausibility. Applicable conditions: Liver Disease

The pharmacokinetic disposition of phentolamine has not been fully determined. Limited data suggest that phentolamine is metabolized by the liver. Phentolamine is eliminated by the kidney and approximately 13% is excreted unchanged in the urine. Therapy with phentolamine should be administered cautiously in patients with severe liver and/or renal function. Clinical monitoring of hepatic and/or renal function is recommended.

References

  1. "Product Information. Regitine (phentolamine)." Ciba Pharmaceuticals, Summit, NJ.

Phentolamine drug interactions

There are 161 drug interactions with phentolamine

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.