Comparing Cuprimine vs Thiola

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Cuprimine penicillamine

Thiola tiopronin

Prescribed for Wilson's Disease, Cystinuria, Rheumatoid Arthritis. Cuprimine may also be used for purposes not listed in this medication guide.

Prescribed for Cystinuria. Thiola may also be used for purposes not listed in this medication guide.

Prescription only

Ratings & Reviews

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Drug Class

Antirheumatics

Miscellaneous genitourinary tract agents

Side Effects

Common side effects include: cheilosis, epigastric pain, glossitis, oral mucosa ulcer, ageusia, and dysgeusia.

See the full Cuprimine side effects document.

See the full Thiola side effects document.

Pricing and Coupons

* Prices are without insurance

Quantity	100 capsule
Dosage	250 mg
Per Unit^*	$273.50
Cost^*	$27,350.44

View all Cuprimine prices and generic prices

Quantity	100 tablet
Dosage	100 mg
Per Unit^*	$29.55
Cost^*	$2,954.54

View all Thiola prices and generic prices

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Generic Availability

Yes

Dosage Form(s) Available

Oral capsule

Oral tablet

Brand Names

Other penicillamine brands include: D-Penamine, Depen, Depen Titratabs Other tiopronin brands include: Thiola EC

Half Life

The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value.

3.2 hours

N/A

CSA Schedule**

View glossary of terms.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Not a controlled drug

Is not subject to the Controlled Substances Act.

Pregnancy Category

Category D Positive evidence of risk

See the full Pregnancy Warnings document.

Category C Risk cannot be ruled out

See the full Pregnancy Warnings document.

Drug Interactions

A total of 91 drugs are known to interact with Cuprimine:

21 major drug interactions (106 brand and generic names)
70 moderate drug interactions (1497 brand and generic names)

No known drug interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Alcohol/Food/Lifestyle Interactions

You may experience reduced absorption of penicillAMINE in the presence of food. The effectiveness... View more

No known alcohol/food interactions. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

First Approval Date

December 04, 1970

August 11, 1988

WADA Class

View World Anti-Doping Agency classifications.

N/A

More Information

** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer