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Thiola Side Effects

Generic name: tiopronin

Medically reviewed by Drugs.com. Last updated on Apr 11, 2023.

Note: This document contains side effect information about tiopronin. Some dosage forms listed on this page may not apply to the brand name Thiola.

Applies to tiopronin: oral tablet, oral tablet delayed release.

Serious side effects of Thiola

Along with its needed effects, tiopronin (the active ingredient contained in Thiola) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking tiopronin:

More common

Incidence not known

Other side effects of Thiola

Some side effects of tiopronin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Incidence not known

For Healthcare Professionals

Applies to tiopronin: oral delayed release tablet, oral tablet.

Hepatic

Postmarketing reports: Jaundice, liver transaminitis[Ref]

Hypersensitivity

Frequency not reported: Drug fever, rash, fever, arthralgia, lymphadenopathy[Ref]

Gastrointestinal

Very common (10% or more): Nausea (25%), diarrhea/soft stools (18%), emesis (10%), oral ulcers (12%)

Frequency not reported: Abdominal pain, abdominal discomfort, abdominal distension, abdominal pain, chapped lips, dry mouth, dyspepsia, eructation, flatulence, GI disorder, gastroesophageal reflux disease[Ref]

Metabolic

Common (1% to 10%): Anorexia[Ref]

Dermatologic

Common (1% to 10%): Rash, ecchymosis, pruritus, urticaria, skin wrinkling

Postmarketing reports: Dry skin, hyperhidrosis, pemphigus foliaceus, skin irritation, skin texture abnormal[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Renal

Postmarketing reports: Nephrotic syndrome, renal failure[Ref]

Respiratory

Common (1% to 10%): Cough[Ref]

Nervous system

Postmarketing reports: Vertigo, ageusia, burning sensation, dizziness, dysgeusia, headache, hypoesthesia, asthenia[Ref]

Musculoskeletal

Very common (10% or more): Arthralgia (12%)

Postmarketing reports: Back pain, flank pain, joint swelling, limb discomfort, musculoskeletal discomfort, myalgia, neck pain, pain in extremity[Ref]

Other

Very common (10% or more): Fatigue/malaise (14%), weakness (12%)

Common (1% to 10%): Fever, peripheral edema

Frequency not reported: Hypogeusia (probably due to chelation of trace metals by this drug)

Postmarketing reports: Pain, peripheral swelling, pyrexia[Ref]

Genitourinary

Frequency not reported: Proteinuria (including nephrotic syndrome), membranous nephropathy, impotence

Cardiovascular

Common (1% to 10%): Chest pain

Postmarketing reports: Congestive heart failure, chest pain

References

1. Product Information. Thiola (tiopronin). Mission Pharmacal Company. 2001.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.