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Tiopronin Pregnancy and Breastfeeding Warnings

Tiopronin is also known as: Thiola, Thiola EC

Medically reviewed by Last updated on Oct 24, 2019.

Tiopronin Pregnancy Warnings

Use is contraindicated.

US FDA pregnancy category: C

-High doses of this drug in animal studies has been shown to interfere with maintenance of pregnancy and viability of the fetus.
-Adequate methods of contraception should be encouraged.
-If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential harm to the fetus.
-Verify negative pregnancy status in females of reproductive potential prior to initiating therapy.

D-penicillamine has been shown to cause skeletal defects and cleft palates in the fetus when given in animal studies at 10 times the dose recommended for human use. A similar teratogenicity might be expected for this drug although no such findings have been verified. There are no controlled data in human pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Tiopronin Breastfeeding Warnings

Use is contraindicated.

Excreted into human milk: Unknown
Excreted into animal milk: Data not available

-This drug can harm a nursing infant.

See references

References for pregnancy information

  1. "Product Information. Thiola (tiopronin)." Mission Pharmaceutical Company, San Antonio, TX.

References for breastfeeding information

  1. "Product Information. Thiola (tiopronin)." Mission Pharmaceutical Company, San Antonio, TX.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.