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Cuprimine Disease Interactions

There are 5 disease interactions with Cuprimine (penicillamine).

Major

Penicillamine (applies to Cuprimine) bone marrow suppression

Major Potential Hazard, High plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts

The use of penicillamine is contraindicated in patients with a history of penicillamine-related aplastic anemia or agranulocytosis.

References

  1. (2001) "Product Information. Cuprimine (penicillamine)." Merck & Co., Inc
Major

Penicillamine (applies to Cuprimine) renal dysfunction

Major Potential Hazard, High plausibility.

Penicillamine is considerably excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. The use of penicillamine is contraindicated in patients with renal dysfunction. Proteinuria and/or hematuria may develop during therapy and may lead to nephrotic syndrome. Monitoring for proteinuria and hematuria is recommended. Caution should be taken and routine monitoring of renal function is recommended.

References

  1. (2001) "Product Information. Cuprimine (penicillamine)." Merck & Co., Inc
Moderate

Penicillamine (applies to Cuprimine) liver disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cholelithiasis

Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.

References

  1. (2001) "Product Information. Cuprimine (penicillamine)." Merck & Co., Inc
Moderate

Penicillamine (applies to Cuprimine) myasthenia gravis

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Goodpasture's Syndrome

The use of penicillamine has been associated with fatalities due to certain diseases such as Goodpasture's syndrome, and myasthenia gravis. Caution is advised in patients with these conditions.

References

  1. (2001) "Product Information. Cuprimine (penicillamine)." Merck & Co., Inc
Moderate

Penicillins (applies to Cuprimine) asthma/allergies

Moderate Potential Hazard, Moderate plausibility.

Penicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.

References

  1. (2009) "Product Information. Penicillin G Procaine (procaine penicillin)." Monarch Pharmaceuticals Inc

Cuprimine drug interactions

There are 105 drug interactions with Cuprimine (penicillamine).

Cuprimine alcohol/food interactions

There are 2 alcohol/food interactions with Cuprimine (penicillamine).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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