Cuprimine Disease Interactions
There are 5 disease interactions with Cuprimine (penicillamine).
Penicillamine (applies to Cuprimine) bone marrow suppression
Major Potential Hazard, High plausibility. Applicable conditions: Bone Marrow Depression/Low Blood Counts
The use of penicillamine is contraindicated in patients with a history of penicillamine-related aplastic anemia or agranulocytosis.
Penicillamine (applies to Cuprimine) renal dysfunction
Major Potential Hazard, High plausibility.
Penicillamine is considerably excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. The use of penicillamine is contraindicated in patients with renal dysfunction. Proteinuria and/or hematuria may develop during therapy and may lead to nephrotic syndrome. Monitoring for proteinuria and hematuria is recommended. Caution should be taken and routine monitoring of renal function is recommended.
Penicillamine (applies to Cuprimine) liver disease
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Cholelithiasis
Cases of intrahepatic cholestasis and toxic hepatitis have been reported with the use of penicillamine. Care should be taken and liver function tests are recommended every six months for the duration of therapy.
Penicillamine (applies to Cuprimine) myasthenia gravis
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Goodpasture's Syndrome
The use of penicillamine has been associated with fatalities due to certain diseases such as Goodpasture's syndrome, and myasthenia gravis. Caution is advised in patients with these conditions.
Penicillins (applies to Cuprimine) asthma/allergies
Moderate Potential Hazard, Moderate plausibility.
Penicillin products should be used with caution in individuals with histories of significant allergies and/or asthma.
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Cuprimine drug interactions
There are 125 drug interactions with Cuprimine (penicillamine).
Cuprimine alcohol/food interactions
There are 2 alcohol/food interactions with Cuprimine (penicillamine).
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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