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Imitrex and Fatigue: What Users Say

Fatigue: mentioned by 7 users (3.4%)

Based on user experiences from 206 Imitrex reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

nausea 12.6%
drowsiness 7.8%
headaches 5.3%
vomiting 5.3%
dizziness 4.9%
pain 4.9%
burning 3.9%
chest pain 3.9%
fatigue 3.4%
hot flashes 3.4%

Reviews for Imitrex

Commonly mentioned side effects
  • Anonymous
  • January 8, 2012

For Migraine "At first, I thought it was great-no headache. Then, the more frequently I used the medication to treat my migraines, the more debilitating side effects I began to experience. I could first mitigate the burning pain and weakness in my head, neck, and jaw and the general feeling of malaise and fatigue by the administration of Naproxen or Ibuprofen prior to the Imitrex, but then, even that ceased to be effective. I finally quit after experiencing total body weakness, a more severe burning pain in my upper extremities than ever before (accompanied by fluctuating hot and cold sensations everywhere else), irregular heartbeat, and irregular breathing after administration. If you experience adverse side effects, it gets worse! Please, find something else."

2 / 10
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25 Report
  • Anonymous
  • January 8, 2012

For Migraine "At first, I thought it was great-no headache. Then, the more frequently I used the medication to treat my migraines, the more debilitating side effects I began to experience. I could first mitigate the burning pain and weakness in my head, neck, and jaw and the general feeling of malaise and fatigue by the administration of Naproxen or Ibuprofen prior to the Imitrex, but then, even that ceased to be effective. I finally quit after experiencing total body weakness, a more severe burning pain in my upper extremities than ever before (accompanied by fluctuating hot and cold sensations everywhere else), irregular heartbeat, and irregular breathing after administration. If you experience adverse side effects, it gets worse! Please, find something else."

2 / 10
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25 Report
  • Rjo...
  • Taken for 1 to 2 years
  • August 6, 2017

For Migraine "When I moved to Indiana, I started getting migraines. My doctor prescribed Imitrex 25 mg, which worked beautifully as long as I took it when the migraine started. Though it still doesn't always work, I take another dose 2 hours after the 1st dose. I developed a tolerance to it and now need to take 50 mg. Fortunately, my migraines have slowed down to a dull roar as I've figured out my triggers. Imitrex has some annoying but mostly tolerable side effects that dissipate with use, such as feeling physically fatigued, feeling kind of drugged, trouble thinking clearly, increased blood pressure/heart rate, sometimes I feel shaky."

8 / 10
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12 Report

Frequently asked questions

  • Anonymous
  • January 25, 2010

For Cluster Headaches "I consider Imitrex to be the greatest medicine in the world, at least as far as my health is concerned. I am never without the auto injector. When a chronic headache comes on, I inject myself, and 3 to 4 minutes later ... no pain. My muscles are fatigued, and I'm somewhat tired for about 30 minutes, but NO PAIN! ... Yes!"

9 / 10
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17 Report
  • Anonymous
  • August 4, 2010

For Migraine "It keeps my migraines from blowing out into severe migraines, but it takes close to an hour to kick in, and when it does, I feel extremely sick, very fatigued for two hours after. Then I have just a mild headache, but I feel like I have a hangover and become forgetful and weak. It is definitely a trade-off, but as severe as my migraine can get, I'll take this until I find another type of medication."

5 / 10
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11 Report

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  • Man...
  • March 21, 2017

For Migraine "Just took it for the first time today, used to use Maxalt. This drug completely knocked me out - so sleepy and tired, not to mention feeling very weird. It's been 7 hours and I feel not great. Headache gone, but left with fatigue and dizziness. Back to Maxalt."

6 / 10
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4 Report
  • hea...
  • Taken for 10 years or more
  • April 2, 2015

For Migraine "Three days on medicine caused extreme muscle pain, tiredness, and weakness. Also, facial flushing, tingling, hot and cold flashes, blurred vision, malaise, increased urination, lack of concentration."

9 / 10
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15 Report

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Reviews may be edited to correct grammar/spelling or remove inappropriate content. Reviews appearing to come from parties with a vested interest are not published. This information is not intended to endorse any medication and should not replace the expertise and judgment of healthcare professionals.