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Sulfamethoxazole / trimethoprim and Rash: What Users Say (Page 2)

Brand names: Bactrim, Bactrim DS, SMZ-TMP DS, Co-trimoxazole, Septra, Septra DS, Bactrim Pediatric, Bactrim IV, Bethaprim Sulfatrim Pediatric Bethaprim Pediatric …show all brand names

Reviews for Sulfamethoxazole / trimethoprim

Commonly mentioned side effects
  • Red...
  • Taken for less than 1 month
  • October 24, 2019

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I was on Bactrim for 7 days for a UTI infection. It cleared it up and didn't seem to have many problems until the last one I took. I broke out in hives, itching everywhere, and I thought I was going to die. I still feel horrible from taking it, with a loss of appetite and anxiety. I will never take this again, as I am now allergic to it. It is now 7 days since I took it and I still feel awful."

5 / 10
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  • Dan...
  • September 15, 2019

Sulfamethoxazole / trimethoprim for Bacterial Skin Infection "I had an ingrown toenail, so my podiatrist removed it and put me on cephalexin for a week. After taking all of them, my toe was still infected. She put me on Bactrim to be taken twice a day for 10 days. Twenty-four hours after my first dose, my mood completely changed. I was depressed and miserable. Day 2, I was spinning, it was impossible to function for daily tasks, and I had no appetite. Day 3, I had a full-blown panic attack, then extreme anxiety, and following that, several heart palpitations. Day 6, I had a rash across my midsection. I stopped taking them that day and called my podiatrist, as my toe still wasn't getting better. She advised I stop and see her later on that day. She wound up removing another piece of nail that had been left behind. When I told her all of the symptoms, she said that I'm allergic. As a person who suffers from food allergies, this terrified me. After a week, the nausea, headache, and spinning started to lighten up, but it took around two months to get back to my normal routine. And to think... these symptoms are NORMAL for this medication."

1 / 10
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  • Jol...
  • Taken for less than 1 month
  • April 21, 2021

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I had the worst experience with Bactrim. The first day, I had a 101.8 fever, chills, uncontrollable shaking, anxiety, rash, and fast heartbeat. The next day, I was extremely achy, nauseous, and could not eat anything the whole day. I stopped taking it after the second day, and my symptoms are getting better after a day, but I still feel cruddy and have a bad headache."

1 / 10
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Frequently asked questions

  • Mam...
  • Taken for less than 1 month
  • May 2, 2018

Sulfamethoxazole / trimethoprim for Bacterial Infection "I was prescribed a 10-day course of Bactrim as a preventative measure after an injury. My wound healed well and no major problems other than nausea until Day 9, when I broke out in a rash. Started on my arms, quickly spread to my trunk, legs, and face. The rash was painful, swollen, and hot to the touch. It felt similar to a bad sunburn. Started taking Benadryl every 4-6 hours until I could get to the doctor, where I got a steroid shot. So far, that seems to be helping a lot. The doctor says I am allergic to sulfa drugs and make sure never to take it again or it could be even worse next time."

5 / 10
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  • Kat...
  • Taken for less than 1 month
  • July 8, 2019

Sulfamethoxazole / trimethoprim for Bacterial Skin Infection "This was my first time taking Bactrim because I’m allergic to penicillin. I had an infection in my big toe due to an ingrown toenail. I give three stars because it did work to clear up the infection. However, on day seven, I began having a severe reaction to the drug. Excruciating pain in my feet, knees, and hips, combined with head-to-toe rash and itching. I took Benadryl and prednisone, and it still took several days to go away. The stuff is horrible. The pain in my joints and lower leg bones was unbearable. Never again."

3 / 10
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  • Sun...
  • Taken for less than 1 month
  • August 11, 2018

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I just took one 160 mg tab of Bactrim. This is the worst pill in history. I got a rash, headache, neck and back pain. Sore throat, bad. My whole body, muscles, and joints are in so much pain. Nausea. My husband has to get me food, put me in the tub to take a hot bath. I feel so weak, OMG. Fever of 101.5, which goes up and down still. Chills and lightheaded. The next day, I still have those symptoms. Gonna call my doc on Monday to give me a different pill. If there was a 0 rating, that's what I would give. Thought I was gonna die."

1 / 10
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  • Anonymous
  • June 2, 2011

Sulfamethoxazole / trimethoprim for Bacterial Skin Infection "I was prescribed Bactrim 2x a day for 30 days for a Staph infection. However, after taking it for about 7 days, I developed a rash. The rash did not itch but started at my shoulders and went down to my legs. I've now begun taking Benadryl to counteract symptoms. So far, it hasn't helped, the rash is still there. As far as the Staph infection, it looks a lot better."

7 / 10
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  • red...
  • September 4, 2011

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "Received a seven-day prescription for Bactrim, and on the 5th day, lost appetite, had terrible body aches, and extreme fatigue. On the 6th day, had a fever and chills too. Stopped the treatment on the 7th day. Then, on the evening of the 8th day, developed a rash all over my upper body and face. Pharmacist recommended Benadryl, which helped somewhat. Having a urinalysis in a week and surely hope it worked and cleared up my urinary tract infection."

5 / 10
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  • Tin...
  • October 11, 2015

For Bacterial Skin Infection "Worst medicine ever. I'm not allergic to anything, by the way. I was prescribed for a UTI and had to stop after 5 days. Migraines, eyeballs throbbed, chest was in excruciating pain, neck pain, upper and lower back pain, stomach and ovary pain, and leg pain, especially in the knees. On top of that, nausea, loss of appetite, dizziness, the immediate and random need to throw up, and worst of all, a red rash all over my body. To top that off, loss of sex drive. I have never had an allergic reaction to a medicine before. I will never take this again. BEWARE!!!!"

1 / 10
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  • Anonymous
  • December 16, 2011

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I used this medication a few times to treat a urinary tract infection, and two times I experienced severe allergic reactions where I had hives on my tongue, neck, and face, and they left scars. Be careful."

1 / 10
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  • Sav...
  • December 18, 2016

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "This is an awful medication, and I recommend it to anyone. Went to the ER for stomach pain to find out I had a bad UTI. Took 1 pill that the doc gave me and was completely fine. Took the next pill 12 hours later, with some saltine crackers and a bottle of water. 4 hours later, I was shaky, nauseated, thought I was going to throw up, my heart rate sped up, I had a fever (did go down with ibuprofen), had a minor rash on my cheeks, headache. Now marks 6 hours after taking it, laying down with a towel over my head, took Benadryl to help with the rash. Nausea has eased some, heating pad helps, the rash is not as red. Going back to the ER tomorrow for a different medicine. I'd rather take Amoxicillin, never have any reactions with that."

1 / 10
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  • Anonymous
  • February 8, 2011

Sulfamethoxazole / trimethoprim for Prevention of Bladder infection "I started taking Bactrim on a Tuesday. By Wednesday, I was depressed and had terrible knots in my stomach. I was going to the bathroom almost every hour and had hives all day and night. Thursday, I felt a lot better, and my symptoms were mostly relieved as well. I thought it was worth the hives and frequent bathroom breaks. On Friday, my lips, gums, tongue, and face were all swollen. I didn't think it was the medication at all. The doc's nurse called to tell me that my culture came back and that they were switching my medicine. When I changed the medicine on Saturday, I had sores in my mouth along with the swollen gums. I made a dental appointment thinking that it was due to an immunization problem. By Sunday, I called my doctor and learned that I developed allergies."

1 / 10
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  • Anonymous
  • August 12, 2009

Sulfamethoxazole / trimethoprim for Bacterial Infection "I had possible strep throat. First day I took it, my fever rose to over 102. I was shaking, chills, rash. My blood pressure (and I have high blood pressure) was 100/55, and my pulse was 50. I was not feeling well at all. I called the doctor the next morning, and he switched me to Amoxicillin. I hope it works better. Now I have an under-the-skin rash all over and am itching. Guess I am allergic to this one."

7 / 10
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  • Anonymous
  • June 6, 2015

Sulfamethoxazole / trimethoprim for Kidney Infections "Rushed to the ER because of unbearable flank pain. Doctor noticed a large amount of white blood cells in the urine and prescribed Bactrim. The first two days I felt okay, nothing really improved. By the fifth day, the back pain disappeared, but the urge to pee was still present. On the sixth day, I got a high fever, headaches, body aches, and a rash. Felt like crap! Stopped taking it and side effects subsided. I'm severely allergic to Bactrim. Was prescribed Cipro, it works great!"

3 / 10
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  • Peg...
  • November 17, 2018

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "NP prescribed Bactrim because I had back-to-back UTIs. Unfortunately, I have an extremely severe allergy to Bactrim that I was not aware of. However, this allergy did not show symptoms until I had been taking it for 6 days. I went to the ER because I was developing a red rash and my throat and tongue were swelling up. The ER doctor turned me away because he thought I had a viral infection. He gave me a Tylenol and sent me home. I ended up going back later that night because I had developed a high fever, headache, and my WBC counts were very low. I saw 10+ different doctors before they could decide if it was actually an allergy. They had to keep me for observation because they were afraid the drug was affecting my internal organs. Did it clear up the UTI? Yes. But if you can avoid the drug, I would suggest you do. If you think you are having an allergic reaction to any drug, please don't let the doctors dismiss you! I didn't trust my gut and I just got sicker because of it."

6 / 10
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  • Sta...
  • September 13, 2019

Sulfamethoxazole / trimethoprim for Bacterial Skin Infection "I was diagnosed with cellulitis in my elbow. The doctor gave me a shot of Bactrim in my bum and sent me home with a prescription for Bactrim 2 times a day. I took it for 4 days, and I developed severe anxiety, chills, overheating, ringing in my ears, and a full-body rash. I was told to stop taking it, and then they gave me prednisone, which made me depressed and full of rage. This medication is awful."

3 / 10
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  • Anonymous
  • December 11, 2011

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I have a severe allergic reaction. I had an extreme rash, with blisters all over my body, including the inside of my mouth. This happened after taking it for three days. It wasn't a positive experience."

6 / 10
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18 Report
  • Syd...
  • Taken for less than 1 month
  • May 10, 2019

Sulfamethoxazole / trimethoprim for Sinusitis "This is horrible medication! I was on Bactrim for only 3 days for sinusitis, then on day 4, I had hives and my face was burning from the inside out but no fever. Went off it. Then day 5, 6, and on 7 now, and my jaw aches and my face feels like it’s going to implode. Strangest feeling. I’m dizzy, have a headache, but the facial tightening and burning are making me crazy. This stuff is scary, and I have no idea when it’s going to stop. Never again."

1 / 10
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  • Goo...
  • Taken for less than 1 month
  • July 16, 2022

Sulfamethoxazole / trimethoprim for Kidney Infections "I was given Bactrim after going to the ER for a rapidly progressing UTI that was making its way to my kidneys (potentially from an infected kidney stone). I was doing okay with Bactrim until days 5-7, when I ran a fever of 101 for 72 hours straight. I went to urgent care on day 6 and asked if the fever might be caused by Bactrim. They said no and pushed that I finish the medication. HOWEVER, on day 8 (after the 7-day dose was complete), I broke out in a full body rash (face and lips included - legs the worst). Though Bactrim did improve my kidney infection symptoms, I still have a UTI, and now I am covered in a rash. If you do have a consistent fever with this medication, and feel like you have the flu (muscle tingling, joint pain, inflamed lymph nodes), this could be an early sign of an allergic reaction! I wish I had stopped sooner when I knew something wasn’t right."

5 / 10
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  • Mid...
  • Taken for less than 1 month
  • February 19, 2019

For Bacterial Infection "I was put on Bactrim for acute prostatitis. I took it for two weeks, and I have never been sicker in my entire life. I had jitters, sweats, severe nausea, and vomiting. I would deal with that, but I have had uncontrollable anxiety and muscle pain in the back of my legs. I have been off of it for a week, and the leg pain and anxiety are still out of control. It caused a mild rash on my sides after taking it. This is the worst thing I have ever taken. I have been in the emergency room three times while on this. I was told by doctors to finish two weeks' worth. I will never take this again."

1 / 10
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  • Anonymous
  • January 16, 2010

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I have taken Bactrim for 3 days. Horrible reaction. Had to go to the hospital. Itch, rashes all over. Also felt like my throat was starting to close up. Had to take 4 pills at the hospital to try to clear up this reaction and to open my airway. I have to take 3 different pills for 8 days. Will have to see my doctor next week to get another medicine for the UTI. Now I know that I'm allergic to this."

2 / 10
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23 Report
  • kmu...
  • April 11, 2009

Sulfamethoxazole / trimethoprim for Urinary Tract Infection "I've taken this to treat and to prevent urinary tract infections, and it has helped me with both. The only reason I gave it an 8 is because if I don't take it for a while, and then I take it, I get hives. The next day when I take it, I'm fine. It just happens the first time. When this happens, I have to take allergy medicine to help it go away."

8 / 10
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  • JTb...
  • March 12, 2015

Sulfamethoxazole / trimethoprim for Prostatitis "After 3 1/2 weeks, I developed a skin rash, which started itching horribly. The rash and itching continued for two weeks (13 days) after stopping the medication. Apparently, sulfa allergies are fairly common. Benadryl helped the itching a bit."

5 / 10
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  • Dea...
  • Taken for less than 1 month
  • May 16, 2020

Sulfamethoxazole / trimethoprim for Sinusitis "I took this as my 3rd round of antibiotics for sinusitis. After taking Bactrim for 4 days, I have been having horrible hives and rashes. I am literally wanting to itch my skin off, it's so bad. I took 2 Benadryl, and I have stopped taking this rubbish. Definitely calling my doctor about these horrible side effects."

2 / 10
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9 Report
  • Dea...
  • Taken for less than 1 month
  • May 16, 2020

Sulfamethoxazole / trimethoprim for Sinusitis "I took this as my 3rd round of antibiotics for sinusitis. After taking Bactrim for 4 days, I have been having horrible hives and rashes. I am literally wanting to itch my skin off, it's so bad. I took 2 Benadryl, and I have stopped taking this rubbish. Definitely calling my doctor about these horrible side effects."

2 / 10
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