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Sofosbuvir and Itching: What Users Say

Brand names: Sovaldi

Itching: mentioned by 4 users (7.8%)

Based on user experiences from 51 Sofosbuvir reviews, the following table shows the most commonly mentioned side effects.

All user comments are moderated by Drugs.com. Each review is verified for relevance and screened for inappropriate content. Side effects are user-reported and not clinically verified.

fatigue 21.6%
nausea 11.8%
headaches 7.8%
itching 7.8%
depression 5.9%
diarrhea 5.9%
insomnia 5.9%
irritability 5.9%
tiredness 5.9%
upset stomach 5.9%

Reviews for Sofosbuvir

Commonly mentioned side effects
  • Ang...
  • November 19, 2016

For Hepatitis C "I was unsuccessfully treated five years ago with Pegasys, interferon, and ribavirin for genotype 3a. I never recovered from the multiple side effects, both physical and cognitive and emotional. I am now on week 9 of the Sovaldi/Daklinza treatment combination. I took my first dose in the evening, and when I awoke and for the next three days, I felt unbelievably wonderful. Clarity of mind, natural optimism, and energy returned to the level of my pre-treatment days. I was stoked! However, this did not last, and since those early days, I have had muscle/joint aches, fatigue, a low mood, itchy face, unsatisfying sleep, and severe neuropathy of the hands/feet (including during the day). I will update at the end of treatment."

4 / 10
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  • Mar...
  • July 2, 2015

For Hepatitis C "Have only been on Sovaldi (and Ribavirin) for three days now, so only have side effects to report on so far. Sovaldi seems to be causing the following: shortness of breath, acid reflux, diarrhea, and a horrible itchiness around my mouth and lips. All but the itchiness are tolerable-the itchiness is preventing me from eating or drinking much liquid, and I hate it. But I remain hopeful that this combo will cure the Hep C I have had for about 43 years now!"

5 / 10
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  • Can...
  • Taken for 1 to 6 months
  • July 5, 2016

For Hepatitis C "I have had hep C for at least 25 years, would not take the old treatment. Now I'm taking Sovaldi/Daklinza. My genotype is 2A and 2C - my viral load was 28 million when I started meds. After 4 weeks, viral load was undetected. Just finished my 6th week today. I'm going through the County Hospital in Dallas, TX. Had no problems getting my meds as Medicare just approved them. So keep trying to find help. I have had very few side effects: mild headache for ten minutes, not even enough to take a Tylenol the first few days. I did itch at the start, took allergy med a few days, and every so often. I feel better taking the hep C meds, my brain fog is better, and I sleep like a baby! I take my meds at 7 pm on time every night and have to go to bed by 9 pm."

10 / 10
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10 Report

Frequently asked questions

  • Me...
  • Taken for 1 to 6 months
  • August 23, 2021

For Hepatitis C "Both HCV geno 3 and treated with Sovaldi/Ribavirin for 24 weeks. Worked every day, although toward the end they almost took me off it due to anemia. SVR still six years out, but downhill decline in health for both my identical twin brother and me. Joint stiffness and pain, fatigue, temperature sensitivity, light sensitivity, no appetite, poor digestion, RUQ pain, itching, memory and concentration issues, Fibro, and on oxygen at night, heart issue, AVN both hips, etc. We both got the COVID vaccine and had a severe reaction. Swelling and weeping clear serum rash resembling a lupus rash and swollen toes and fingertips turned purple, painful burning with petechiae. Lasted two weeks. Went away for five days and reoccurred to a lesser extent, still ongoing. The ER called it hives, while I have photos of the day by day and symptoms were present at the visit. Ever see hives with petechiae? The biggest challenge is to find a doc who listens and reads. Feel like it’s almost over here for me. No regrets."

5 / 10
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