Siponimod User Reviews & Ratings

• Too...
• Taken for 1 to 6 months
• January 22, 2023

Siponimod for Multiple Sclerosis "While I was on Mayzent, I started experiencing blurred vision, jerking, stuttering, and frequent falls. My MS was getting worse, not better. My quadriceps in my left leg have stopped working, and I cannot lift my leg more than an inch off of the floor. My left foot drags when I walk, and now I have to use a bench to get in and out of the shower. I have had several incidents since I started taking this drug. I cannot walk without a cane because my dragging foot causes me to fall flat on my face. I have had to have a spinal fusion due to the falls causing me to have pinched nerves. I have now been put on Ocrevus twice a year infusion, and I no longer suffer from stuttering, jerking, double vision, or falls, however, most of my damage cannot be corrected. I wish I had never used this drug for my treatment of Secondary Progressive Multiple Sclerosis. Completely devastated."

• Xed...
• Taken for 6 months to 1 year
• May 12, 2023

Siponimod for Multiple Sclerosis "I have secondary progressive MS. I was offered this medication as the only available option for me in Canada with SPMS. I was eager to try it. I found my MS got worse. My friends and family members noticed it too. My fatigue, my spasticity, my mobility instantly declined. My doctor wanted me to give it a fair try, as it was the only option for 6 months. I was very vocal it had made me worse. Following that, my doctor took me off."

• Bea...
• Taken for 6 months to 1 year
• October 17, 2021

Siponimod for Multiple Sclerosis "Black Male, Dx Aug 2020. I was on this drug for about 1 year. While on it, I was a mental wreck. Extremely bad brain fog. Physically, I hurt a lot and used a cane from time to time. It didn't work for me, I was a breakthrough case. I averaged 5,000 steps a day while on the drug. Two days off the med, and I was able to walk a mile with no assistance. Now I'm about 4 weeks off, and I've been doing 10,000 step days. (Mind you, just doing house stuff)."

• Anonymous
• Taken for 1 to 2 years
• November 23, 2021

Siponimod for Multiple Sclerosis "I have been on Mayzent for a little over a year now, and I'm pleased with it. I was diagnosed with MS in 2004. My neurologist at the time started me on Copaxone. It worked for me for 15 years. I had no new lesions. Then my insurance company bullied me to switch to the generic version of Copaxone by threatening to not pay for the medication. I was on the generic version for a little over 6 months before I started having new lesions. My neurologist switched me to Mayzent. I was a little skeptical at first reading about the possible side effects. After taking it now for a little over a year, I'd have to say I'm pleased with this medication. I haven't experienced any side effects, nor do I have any new lesions. Thank you, Lord!"

• Mas...
• Taken for 1 to 6 months
• September 16, 2020

Siponimod for Multiple Sclerosis "I have been taking this drug for 6 months. I haven't noticed any side effects. This is delivered to my door each month in a box filled with ice packs because it has to be refrigerated. I also have a Mayzent representative that calls me every month to check on me and to see if anything has changed since the prior month. Overall, I feel it's better and easier than the shot I was having to give myself. I would recommend this."

• Ker...
• Taken for 2 to 5 years
• March 28, 2024

Siponimod for Multiple Sclerosis "I was diagnosed in 1999. I have been on many MS medications, including Novantrone, Avonex, Copaxone, IVIG, steroids, and now Mayzent. I just had MRIs done in 2023, and lo and behold, my lesions are almost nonexistent! They have all but disappeared, and my new neurologist doesn’t feel I even have MS! After 25 years, I’m looking at a possible misdiagnosis or is the Mayzent working? I personally feel the Mayzent is working! So much better than IV infusions and shots you have to do yourself! So grateful I’m on Mayzent!"

• Zen...
• Taken for 1 to 6 months
• May 4, 2023

Siponimod for Multiple Sclerosis "So, it's hot out today, and I'm making my bed, but I'm complaining about the sweat dripping down my face and neck. Then I realized, 'OMG! I'm sweating!' You must understand and excuse my language, but I haven't been able to sweat in ten years. Sure, I'd get burning hot while riding a bike, but I'd only get maybe a drop of sweat on my forehead, feeling like I was going to fall over dead. But I started taking Mayzent three months ago, and I didn't feel like I was going to drop. I just dripped sweat like a normal person! Yeah! Mayzent is my miracle, and I'm still experiencing small changes every day, including sweat!"

• Gre...
• Taken for 2 to 5 years
• June 18, 2025

Siponimod for Multiple Sclerosis "I began Mayzent several years ago, and because I tested positive for a specific genotype, I was put on the maintenance dose of 4 x 0.25 mg. This was a true miracle for me. I had no side effects, and my walking actually improved. Over recent years, I've even had a gradual improvement in my cog fog issues and have been working hard to complete my university thesis. Then on the 01 May 2025, my chemist informed me the company Novartis had discontinued my 120 x 0.25 mg monthly maintenance pkts (it wasn't commercially viable) and introduced a 28 x 1 mg pkt as an alternative. My deterioration has been shocking. I was raced to the hospital a few weeks back with a BP of 220. I am covered in bruises from falls. My legs are dragging. I'm in increasing pain. There was a time when I had hope as my Secondary Progressive Multiple Sclerosis had slowed almost to a halt over 4 years, and with no notice, no compassionate programs in place, my future has been destroyed... completely and utterly devastated."

• Gre...
• Taken for 2 to 5 years
• June 18, 2025

Siponimod for Multiple Sclerosis "I began Mayzent several years ago, and because I tested positive for a specific genotype, I was put on the maintenance dose of 4 x 0.25 mg. This was a true miracle for me. I had no side effects, and my walking actually improved. Over recent years, I've even had a gradual improvement in my cogfog issues and have been working hard to complete my university thesis. Then on the 01 May 2025, my chemist informed me the company Novartis had discontinued my 120 x 0.25 mg monthly maintenance packets (it wasn't commercially viable) and introduced a 28 x 1 mg packet as an alternative. My deterioration has been shocking. I was raced to the hospital a few weeks back with a BP of 220. I am covered in bruises from falls. My legs are dragging. I'm in increasing pain. There was a time when I had hope as my Secondary Progressive Multiple Sclerosis had slowed almost to a halt over 4 years, and with no notice, no compassionate programs in place, my future has been destroyed, completely and utterly devastated."

• Ano...
• Taken for 1 to 2 years
• May 24, 2025

Siponimod for Multiple Sclerosis "I have been taking Mayzent for almost 2 years. Before this drug, I was taking Rebif since 2000, over 20 years. Works better than taking needles. No fever and flu symptoms. No new lesions. Going for a new MRI this year."

• Anonymous
• Taken for 1 to 6 months
• September 23, 2020

Siponimod for Multiple Sclerosis "My experience is I have been using 3 months. No side effects!"

• Dia...
• Taken for less than 1 month
• April 25, 2022

For Multiple Sclerosis "Was nervous about potential side effects, so kept a diary. Nothing to worry about. Finished siponimod today, starting maintenance tomorrow. I will update in 6 weeks. Take care, everyone."